Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds.
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Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductanceThe sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substratesMechanisms of glutamate transportExcitatory amino acid transporters: roles in glutamatergic neurotransmissionMolecular dynamics simulations of the mammalian glutamate transporter EAAT3Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporterThe density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNSThe effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activationIndividual subunits of the glutamate transporter EAAC1 homotrimer function independently of each otherInhibition of isoflurane-induced increase of cell-surface redistribution and activity of glutamate transporter type 3 by serine 465 sequence-specific peptidesTime-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter.Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.The central cavity in trimeric glutamate transporters restricts ligand diffusion.Glutamate transporter EAAC1 is expressed on Müller cells of lower vertebrate retinas.Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1Rapid substrate-induced charge movements of the GABA transporter GAT1.Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.Fast homeostatic plasticity of inhibition via activity-dependent vesicular fillingDisulfide cross-linking of transport and trimerization domains of a neuronal glutamate transporter restricts the role of the substrate to the gating of the anion conductanceGlial and Neuronal Glutamate Transporters Differ in the Na+ Requirements for Activation of the Substrate-Independent Anion ConductanceNeuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampusMechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5.A conserved methionine residue controls the substrate selectivity of a neuronal glutamate transporter.Turnover rate of the gamma-aminobutyric acid transporter GAT1.Novel properties of a mouse gamma-aminobutyric acid transporter (GAT4).The importance of the excitatory amino acid transporter 3 (EAAT3)Hetero-oligomerization of neuronal glutamate transportersWhy glycine transporters have different stoichiometries.Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion.Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) Ligands with Novel Serine AnalogsA conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transportersConserved asparagine residue located in binding pocket controls cation selectivity and substrate interactions in neuronal glutamate transporter.A channel in a transporter.Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling.Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter.Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1.Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-BProtonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1
P2860
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P2860
Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds.
description
2000 nî lūn-bûn
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2000年の論文
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@zh-mo
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@wuu
name
Glutamate translocation of the ...... C1 occurs within milliseconds.
@ast
Glutamate translocation of the ...... C1 occurs within milliseconds.
@en
type
label
Glutamate translocation of the ...... C1 occurs within milliseconds.
@ast
Glutamate translocation of the ...... C1 occurs within milliseconds.
@en
prefLabel
Glutamate translocation of the ...... C1 occurs within milliseconds.
@ast
Glutamate translocation of the ...... C1 occurs within milliseconds.
@en
P2093
P2860
P356
P1476
Glutamate translocation of the ...... C1 occurs within milliseconds.
@en
P2093
P2860
P304
P356
10.1073/PNAS.160170397
P407
P577
2000-08-01T00:00:00Z