Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.
about
Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determinationWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkImportin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domainThe 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityThe interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNAStructural basis of nuclear import of flap endonuclease 1 (FEN1)Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairsThe protein components and mechanism of eukaryotic Okazaki fragment maturation.Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and developmentHigh mobility of flap endonuclease 1 and DNA polymerase eta associated with replication foci in mammalian S-phase nucleus.Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavageMethylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA bindingIncreases in mitochondrial DNA content and 4977-bp deletion upon ATM/Chk2 checkpoint activation in HeLa cells.Functional regulation of FEN1 nuclease and its link to cancerThe Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae.Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instabilityHigh risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant miceThe trans-autostimulatory activity of Rad27 suppresses dna2 defects in Okazaki fragment processing.Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast geneticsNucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathwaysMapping the FEN1 interaction domain with hTERT.Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair.Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region.Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay.DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair.Interaction interface of human flap endonuclease-1 with its DNA substrates.Fen1 does not control somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat in a knock-in mouse model for DM1.
P2860
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P2860
Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Cell cycle-dependent and DNA d ...... in DNA replication and repair.
@ast
Cell cycle-dependent and DNA d ...... in DNA replication and repair.
@en
type
label
Cell cycle-dependent and DNA d ...... in DNA replication and repair.
@ast
Cell cycle-dependent and DNA d ...... in DNA replication and repair.
@en
prefLabel
Cell cycle-dependent and DNA d ...... in DNA replication and repair.
@ast
Cell cycle-dependent and DNA d ...... in DNA replication and repair.
@en
P2093
P2860
P356
P1476
Cell cycle-dependent and DNA d ...... in DNA replication and repair.
@en
P2093
P2860
P304
P356
10.1074/JBC.M007825200
P407
P577
2000-10-25T00:00:00Z