The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
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A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cellsEndoplasmic reticulum stress and type 2 diabetesEndoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetesIt's all in your mind: determining germ cell fate by neuronal IRE-1 in C. elegansMelatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cellsGlucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.Transcriptional regulation of VEGF-A by the unfolded protein response pathway.A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice.Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis.IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.ER stress, autophagy, and RNA viruses.Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitisDirect association of unfolded proteins with mammalian ER stress sensor, IRE1βIdentification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure.Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial CellsIRE1α activation protects mice against acetaminophen-induced hepatotoxicityThe IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.Endoplasmic reticulum stress and insulin biosynthesis: a reviewThe unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis.Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death.Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.Beta-cell failure as a complication of diabetes.Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsOxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species.Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver?Regulation of the unfolded protein response by microRNAs.Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress.Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetesThe binary switch between life and death of endoplasmic reticulum-stressed beta cellsA switch from life to death in endoplasmic reticulum stressed β-cells.The binary switch that controls the life and death decisions of ER stressed β cells.
P2860
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P2860
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@ast
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@en
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@nl
type
label
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@ast
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@en
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@nl
prefLabel
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@ast
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@en
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@nl
P2093
P2860
P1433
P1476
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
@en
P2093
Fumihiko Urano
Kathryn L Lipson
Rajarshi Ghosh
P2860
P356
10.1371/JOURNAL.PONE.0001648
P407
P577
2008-02-20T00:00:00Z