Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.
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Mammalian Krüppel-like factors in health and diseasesThe double life of KLF5: Opposing roles in regulation of gene-expression, cellular function, and transformationInvestigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestinesIdentification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screeningIntersection of AHR and Wnt signaling in development, health, and disease.Interruption of KLF5 acetylation converts its function from tumor suppressor to tumor promoter in prostate cancer cells.Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathwaysHelicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo.Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells.Krüpple-like factor 5 is required for proper maintenance of adult intestinal crypt cellular proliferation.Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells.Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestineLoss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancerML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer.More than two decades of Apc modeling in rodentsA colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α).Role of Krüppel-like factors in cancer stem cells.Krüppel-like factors in hepatocellular carcinoma.Krüppel-like factors in mammalian stem cells and development.Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon.SP and KLF Transcription Factors in Digestive Physiology and Diseases.Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses.Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma.Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.Aging and the Krüppel-like factors.KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-RasG12D expression.
P2860
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P2860
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.
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2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010 թվականի մարտին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
Krüppel-like factor 5 is a cru ...... ApcMin and KRASV12 mutations.
@ast
Krüppel-like factor 5 is a cru ...... ApcMin and KRASV12 mutations.
@en
type
label
Krüppel-like factor 5 is a cru ...... ApcMin and KRASV12 mutations.
@ast
Krüppel-like factor 5 is a cru ...... ApcMin and KRASV12 mutations.
@en
prefLabel
Krüppel-like factor 5 is a cru ...... ApcMin and KRASV12 mutations.
@ast
Krüppel-like factor 5 is a cru ...... ApcMin and KRASV12 mutations.
@en
P2093
P2860
P356
P1433
P1476
Krüppel-like factor 5 is a cru ...... ApcMin and KRASV12 mutations.
@en
P2093
Amr M Ghaleb
Beth B McConnell
Mandayam O Nandan
Nilesh V Patel
Sylvie Robine
Vincent W Yang
P2860
P2888
P356
10.1186/1476-4598-9-63
P577
2010-03-18T00:00:00Z
P5875
P6179
1039900093