Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier - Wikidata - awgldk - TriplyDB

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

http://www.wikidata.org/entity/Q33816018

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Claudins in intestines: Distribution and functional significance in health and diseases From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity Guanylyl cyclase C signaling axis and colon cancer prevention Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.Sildenafil normalizes bowel transit in preclinical models of constipation Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis.Effect of guanylate cyclase-C activity on energy and glucose homeostasis Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen.A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation.Brief report: Dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury.Intracellular mediators of JAM-A-dependent epithelial barrier function.Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis.Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index.Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa GUCY2C ligand replacement to prevent colorectal cancer.Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium.The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis.Products for the treatment of inflammatory bowel disease: a patent review (2013 - 2014).cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.Molecular Physiology of Membrane Guanylyl Cyclase Receptors.Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer.Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue.Secretome of Intestinal Bacilli: A Natural Guard against Pathologies.GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.Murine guanylate cyclase C regulates colonic injury and inflammation.Differentially expressed genes in the caecal and colonic mucosa of Landrace finishing pigs with high and low food conversion ratios.GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress.A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo.Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice.Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models.Effects of Thymoquinone on radiation enteritis in mice Clinical utility of plecanatide in the treatment of chronic idiopathic constipation

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Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

http://www.wikidata.org/entity/Q33816018

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

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Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

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type

label

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

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Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

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prefLabel

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

@ast

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

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JOURNAL.PONE.0016139

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Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

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Elizabeth Mann

http://www.w3.org/2001/XMLSchema#string

Kris A Steinbrecher

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Marshall H Montrose

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Shila Gilbert

http://www.w3.org/2001/XMLSchema#string

Yanfang Guan

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P2860

Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.

Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load

Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity

Guanylyl cyclase is a heat-stable enterotoxin receptor

Intestinal mucosal barrier function in health and disease

The primary defect in experimental ileitis originates from a nonhematopoietic source.

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease.

Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse

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scholarly article

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10.1371/JOURNAL.PONE.0016139

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1

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Mitchell B. Cohen

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2011-01-31T00:00:00Z

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49821083

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21305056

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3031533

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