The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
about
Machado-Joseph Disease: from first descriptions to new perspectives.Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationCrystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activityThe UBL domain of PLIC-1 regulates aggresome formationThe UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradationTargeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cellsCell biology of spinocerebellar ataxiaProtein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C TerminiAggresome formation and neurodegenerative diseases: therapeutic implicationsProteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chainsProteotoxic stress increases nuclear localization of ataxin-3Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIPRuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.Trinucleotide repeats: a structural perspectiveHistone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disordersUbiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting.PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.Nucleocytoplasmic shuttling activity of ataxin-3.Ataxin-3 promotes genome integrity by stabilizing Chk1.Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable.Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionThe role of ubiquitin in autophagy-dependent protein aggregate processingp62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamineActivity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.Versatile roles of k63-linked ubiquitin chains in trafficking.The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.Allosteric regulation of deubiquitylase activity through ubiquitination.Toward understanding Machado-Joseph diseaseIsolation of aggresomes and other large aggregatesAtaxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.Basal and stress-induced Hsp70 are modulated by ataxin-3.Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa.Machado-Joseph disease/spinocerebellar ataxia type 3.Class IIA HDACs in the regulation of neurodegeneration.Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery.Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia
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P2860
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
@ast
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
@en
type
label
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
@ast
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
@en
prefLabel
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
@ast
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
@en
P2860
P356
P1476
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
@en
P2093
Barrington G Burnett
Randall N Pittman
P2860
P304
P356
10.1073/PNAS.0407252102
P407
P577
2005-03-14T00:00:00Z