Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor ex

Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor ex

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The Role of PPARs in Cancer Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human Dietary effects of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal gene expression Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities Cross-species gene expression analysis of species specific differences in the preclinical assessment of pharmaceutical compounds Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs.Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4.Liver fatty acid-binding protein targets fatty acids to the nucleus. Real time confocal and multiphoton fluorescence imaging in living cells.Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species.Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals.Simulating quantitative cellular responses using asynchronous threshold Boolean network ensembles.PPARs, Obesity, and Inflammation Identification of genes related to beak deformity of chickens using digital gene expression profiling Cytochrome P450 and xenobiotic receptor humanized mice.Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans.PPAR-alpha effects on the heart and other vascular tissues.Genomics and the search for novel biomarkers in toxicology.Tissue-selective, bidirectional regulation of PEX11 alpha and perilipin genes through a common peroxisome proliferator response element.Genetic-dependency of peroxisomal cell functions - emerging aspects.Effect of a Large Dose of Di (2-ethylhexyl) phthalate (DEHP) on Hepatic Peroxisome in Cynomolgus Monkeys (Macaca Fascicularis).PPARalpha agonist-induced rodent tumors: modes of action and human relevance.Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors.Application of genomics in preclinical drug safety evaluation.Investigational PPAR-gamma agonists for the treatment of Type 2 diabetes.Cross-species comparative toxicogenomics as an aid to safety assessment.The PPAR-alpha activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs.Role of signalling systems in the effects of dietary factors on the expression of mammalian CYPs.Rosiglitazone and bezafibrate modulate gene expression in a rat model of non-alcoholic fatty liver disease--a historical prospective Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation.Role of peroxisome proliferator-activated receptor alpha in the control of cyclooxygenase 2 and vascular endothelial growth factor: involvement in tumor growth.Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model.Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation.The evolution of gene expression studies in drug safety assessment.Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.IL-6 cooperates with peroxisome proliferator-activated receptor-α-ligands to induce liver fatty acid binding protein (LFABP) up-regulation.TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model.Acyl-coenzyme A oxidases 1 and 3 in brown trout (Salmo trutta f. fario): Can peroxisomal fatty acid β-oxidation be regulated by estrogen signaling?

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Q21342955-9299A250-C9F6-4030-9AF3-AF3CBF05CC1E Q21562369-C24876F9-6735-486D-806F-449A04058DB0 Q24793805-F804A456-DB5F-4FB2-A635-ED7DAE533F6D Q28183207-98D8348E-DA11-4C5D-AD2E-8759BE082052 Q28290987-0950B5A9-F8A3-4FEB-AD83-780D8818A4D3 Q28538757-01C88BC2-66DE-47BA-BAD2-28CB158BC34B Q30319871-5766563E-D6AD-4743-98E1-2DE89C2CA862 Q30764627-3EE1BF13-EC4D-45A4-9C41-4903D0CFC914 Q31060634-A49C8E80-005D-416D-A17A-CF11D3BADBB4 Q33210856-1A61ACA4-7448-40CC-9368-8350F8E04D3F Q33254375-11E970DB-38E0-4EFA-AD0F-A9A8096BC040 Q33957286-84CBE6C9-88EA-4394-9BBD-2214D30F46AA Q34003196-AB470BE9-09EA-490B-A5C5-81AD00809297 Q34150066-0590897B-142F-4692-9FB2-2F829A6B4EEF Q34545343-AEAA70FC-5EFE-49FD-828E-38C075294CEA Q34808268-D6856A0C-F2A1-4EEC-A4AE-0529D363DA60 Q35000567-FF28D9EE-799E-48BB-966E-453AF4DA409C Q35080447-8756DF07-D164-4ADC-B294-804DE4F5F88F Q35140486-6FD9FDDE-A63C-43E4-99E3-FEF10D9E31CB Q35544705-99BD2B32-E778-4C04-AC5B-B6901E1080BA Q35574139-255D4F42-E64D-494B-B1EA-1C26C03D6433 Q35603991-379B06B5-873F-4F04-A01E-BE69A05C65B1 Q35631058-7749AF5F-0D2C-4C74-A5D2-7AA9C9C0CFCF Q35859116-B1A84FE5-1948-486B-9FB6-F484548E4C13 Q36478801-5FB9F19C-657E-480F-B370-641FC7D7FEA9 Q36512559-13452DDE-EDC8-4C55-B5A6-F4C5A7759234 Q36662861-D8AEA1B5-A23B-4FBD-9499-24D95B4DC998 Q36787467-8768DA01-C6DA-4958-80BC-17D6989C364C Q36788404-696BC0E6-6241-406C-95DC-999BD12B44C2 Q36814812-7C697D57-A697-4DEF-BCCD-5D70DACDF820 Q36927688-C201CA6D-B829-451E-874D-601FB691C7C8 Q36929610-6230E015-EDB8-4EE0-A555-BA025838804B Q37231752-A8A2F507-2A31-4E29-A5FB-BF21A4CFB79B Q37269176-4391C9EE-8EEA-43DA-8239-9F07C0140F76 Q37557621-5AB6C278-53EC-4CBE-80E9-78E8EAB96A5E Q37658709-64536D76-0BF8-453C-AFD7-12A7454DA06B Q38158164-20696EC1-8330-4F71-8C4C-D1D0035F70D6 Q38316712-E16DEBFF-CB33-44EB-81A2-98C05ECDF8EC Q39911368-D54F4948-28E6-46E8-AD0B-EE36FFFD9DA7 Q40385677-E3DA4AF7-E8AE-454E-A017-ADC9918E8F56

P2860

Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor ex

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2001 nî lūn-bûn

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2001 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2001 թվականի հունիսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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