C-terminal invariable domain of VlsE is immunodominant but its antigenicity is scarcely conserved among strains of Lyme disease spirochetes
about
Borrelia burgdorferi changes its surface antigenic expression in response to host immune responsesvls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework HeterogeneityPersistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infectionCrystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferiUse of Peptide library screening to detect a previously unknown linear diagnostic epitope: proof of principle by use of lyme disease sera.Dogs vaccinated with common Lyme disease vaccines do not respond to IR6, the conserved immunodominant region of the VlsE surface protein of Borrelia burgdorferi.Evidence that the variable regions of the central domain of VlsE are antigenic during infection with lyme disease spirochetes.Epitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndromeBorrelia burgdorferi spirochetes that harbor only a portion of the lp28-1 plasmid elicit antibody responses detectable with the C6 test for Lyme diseaseSerum antibodies to whole-cell and recombinant antigens of Borrelia burgdorferi in cottontail rabbits.Dominant epitopes of the C6 diagnostic peptide of Borrelia burgdorferi are largely inaccessible to antibody on the parent VlsE moleculeAn immune evasion mechanism for spirochetal persistence in Lyme borreliosis.Experimental infections of the reservoir species Peromyscus leucopus with diverse strains of Borrelia burgdorferi, a Lyme disease agent.Effect of Borrelia burgdorferi genotype on the sensitivity of C6 and 2-tier testing in North American patients with culture-confirmed Lyme disease.Analysis of Borrelia burgdorferi vlsE gene expression and recombination in the tick vector.Significant improvement of the recombinant Borrelia-specific immunoglobulin G immunoblot test by addition of VlsE and a DbpA homologue derived from Borrelia garinii for diagnosis of early neuroborreliosis.Comparison of the Borrelia DotBlot G, MarDx, and VIDAS enzyme immunoassays for detecting immunoglobulin G antibodies to Borrelia burgdorferi in human serum.Antibody Response to Lyme Disease Spirochetes in the Context of VlsE-Mediated Immune Evasion.Antigenicity and recombination of VlsE, the antigenic variation protein ofBorrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete
P2860
Q24561576-D86C9F2F-A709-4210-8473-54C71127C09BQ26829575-7F27B4C1-4F9F-464D-931C-2341D7E9ABDFQ27310210-9F9BDD0D-DB8A-4C4B-B489-C3672585E52DQ27638660-C95F4927-9CAA-4A12-895A-764FF4EF40F8Q30448319-62013934-D64E-459E-8CE3-7D3E815B9F6CQ33711842-250D5E3E-9E1C-4CF2-BBF9-16AD65D9CAA6Q34127718-C109F8FD-7DFD-4830-AF4F-CFFFFF4B6E10Q34202515-853A0430-1082-4CC8-95B5-4A52F12FBF4BQ35635857-7B20910F-6978-44A9-8D1A-EF7C0789B25BQ35681719-D4E3BFC2-520E-4E4B-A4DF-4F9950A1FDD3Q36097158-A32A3A3B-45A3-435D-81E6-9C6285193F97Q36369900-C12E72C5-CEEE-413B-BF4A-BC2A60FB2454Q36454949-C5889D76-D7FD-40BB-89F6-57FF3B1423A5Q37412783-EBF395BB-CFB2-4F56-AB1D-AEF95CB90736Q39529629-DBD110B9-19EE-4D73-AE5F-263EB780F001Q39735336-0017F6C9-01D4-4525-A258-5B01AF1E1063Q39750987-00D4BA21-A434-4C7E-B567-A0546455BCB6Q40442730-AF55DAC2-0FEB-4B8A-BC3D-2C79C71EA139Q57889516-B17E5079-6808-4C0A-B88C-B3EA7E9B8C8D
P2860
C-terminal invariable domain of VlsE is immunodominant but its antigenicity is scarcely conserved among strains of Lyme disease spirochetes
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@ast
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@en
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@nl
type
label
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@ast
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@en
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@nl
prefLabel
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@ast
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@en
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@nl
P2093
P2860
P1476
C-terminal invariable domain o ...... ns of Lyme disease spirochetes
@en
P2093
L C Bowers
M T Philipp
P2860
P304
P356
10.1128/IAI.69.5.3224-3231.2001
P407
P577
2001-05-01T00:00:00Z