NQO1 stabilizes p53 through a distinct pathway. - Wikidata - awgldk - TriplyDB

NQO1 stabilizes p53 through a distinct pathway.

NQO1 stabilizes p53 through a distinct pathway.

http://www.wikidata.org/entity/Q34016489

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Implications of NQO1 in cancer therapy Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73 Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer.Cytoprotection "gone astray": Nrf2 and its role in cancer Impairment of antioxidant defenses as a contributor to arsenite-induced cell transformation An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer Robust concentration and frequency control in oscillatory homeostats LAS0811: from combinatorial chemistry to activation of antioxidant response element.NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gamma-dependent growth arrest.TP53, MDM2, NQO1, and susceptibility to cervical cancer.PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.NAD(P)H:quinone oxidoreductase 1 is induced by progesterone in cardiomyocytes.NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion.A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1 A functional NQO1 609C>T polymorphism and risk of hepatocellular carcinoma in a Chinese population.The NQO1 allelic frequency in hindu population of central India varies from that of other Asian populations.Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinoma.The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress.NRH:quinone oxidoreductase 2-deficient mice are highly susceptible to radiation-induced B-cell lymphomas Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes.p53, aerobic metabolism, and cancer.Calcium and reactive oxygen species in acute pancreatitis: friend or foe?Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer.The NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer.Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53.A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.Quinone reductases multitasking in the metabolic world.Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro.Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

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P2860

NQO1 stabilizes p53 through a distinct pathway.

http://www.wikidata.org/entity/Q34016489

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2002 nî lūn-bûn

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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2002 թվականի փետրվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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NQO1 stabilizes p53 through a distinct pathway.

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NQO1 stabilizes p53 through a distinct pathway.

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NQO1 stabilizes p53 through a distinct pathway.

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type

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NQO1 stabilizes p53 through a distinct pathway.

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NQO1 stabilizes p53 through a distinct pathway.

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NQO1 stabilizes p53 through a distinct pathway.

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NQO1 stabilizes p53 through a distinct pathway.

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NQO1 stabilizes p53 through a distinct pathway.

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NQO1 stabilizes p53 through a distinct pathway.

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Proceedings of the National Academy of Sciences of the United States of America

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NQO1 stabilizes p53 through a distinct pathway.

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P2093

Gad Asher

http://www.w3.org/2001/XMLSchema#string

Joseph Lotem

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Leo Sachs

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Rachel Kama

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Yosef Shaul

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P2860

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

A model for p53-induced apoptosis

Mdm2 promotes the rapid degradation of p53

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells

Regulation of p53 stability by Mdm2

p53, the cellular gatekeeper for growth and division

Surfing the p53 network

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

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3099-3104

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scholarly article

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10.1073/PNAS.052706799

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5

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99

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11867746

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122479

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