Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes - Wikidata - awgldk - TriplyDB

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes

http://www.wikidata.org/entity/Q34055205

about

Adenovirus E1B 55K represses p53 activation in vitro.AMF1 (GPS2) modulates p53 transactivation The first 30 years of p53: growing ever more complex Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis Therapeutic considerations for Mdm2: not just a one trick pony p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53 Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53 The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor.Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma.pRB induces Sp1 activity by relieving inhibition mediated by MDM2.A functional p53-responsive intronic promoter is contained within the human mdm2 gene.A small nuclear RNA, hdm365, is the major processing product of the human mdm2 gene.Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions.DNA damage induces phosphorylation of the amino terminus of p53 p53 induction is associated with neuronal damage in the central nervous system The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein.MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins.Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation Cell type-specific inhibition of p53-mediated apoptosis by mdm2.Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant High levels of MDM2 are not correlated with the presence of wild-type p53 in human malignant mesothelioma cell lines.Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2 Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities.Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene.Loss of p53 function through PAX-mediated transcriptional repression.A temperature-sensitive mutant of human p53.Wild-type alternatively spliced p53: binding to DNA and interaction with the major p53 protein in vitro and in cells.Mdm2 and MdmX as Regulators of Gene Expression The Functional Roles of the MDM2 Splice Variants P2-MDM2-10 and MDM2-∆5 in Breast Cancer Cells MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.A new coactivator function for Zac1's C2H2 zinc finger DNA-binding domain in selectively controlling PCAF activity.A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis Amplification of MDM2 inhibits MyoD-mediated myogenesis.Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression.

P2860

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P2860

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes

http://www.wikidata.org/entity/Q34055205

description

1993 nî lūn-bûn

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1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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1993 թվականի հուլիսին հրատարակված գիտական հոդված

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1993年の論文

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1993年論文

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1993年論文

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1993年論文

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1993年論文

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1993年論文

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1993年论文

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name

Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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label

Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

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P356

J.1460-2075.1993.TB05941.X

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The EMBO Journal

P1476

Sequence-specific DNA binding ...... inding to p53 - MDM2 complexes

@en

P2093

A Zauberman

http://www.w3.org/2001/XMLSchema#string

M Oren

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N Levy

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N Ragimov

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Y Barak

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P2860

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription

Definition of a consensus binding site for p53

Oncogenic forms of p53 inhibit p53-regulated gene expression

Amplification of a gene encoding a p53-associated protein in human sarcomas

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Identification of p53 as a sequence-specific DNA-binding protein

p53 mutations in human cancers

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product

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2799-2808

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scholarly article

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10.1002/J.1460-2075.1993.TB05941.X

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7

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12

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1993-07-01T00:00:00Z

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8334996

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413530

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