Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate.
about
Nanoparticles for brain drug deliveryUptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancerThe Role of Cell-Penetrating Peptide and Transferrin on Enhanced Delivery of Drug to BrainPromising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer.Biotechnology: Crossing the barrierCurrent approaches to enhance CNS delivery of drugs across the brain barriersPotential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid BarrierSelective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein.IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey.Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse.Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor.Identifying blood-brain-barrier selective single-chain antibody fragments.Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex.Brain-specific expression of an exogenous gene after i.v. administration.Vector-mediated drug delivery to the brain.Functional expression and localization of P-glycoprotein at the blood brain barrier.CNS delivery via adsorptive transcytosis.Insulin receptor antibody-sulfamidase fusion protein penetrates the primate blood-brain barrier and reduces glycosoaminoglycans in Sanfilippo type A cells.A novel vascular targeting strategy for brain-derived endothelial cells using a TCR mimic antibody.Brain-penetrating tumor necrosis factor decoy receptor in the mouse.Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein.Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein.A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding.Noninvasive gene targeting to the brainDelivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein.Transcytosis: crossing cellular barriers.Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor.The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain BarrierIntravenous, non-viral RNAi gene therapy of brain cancer.Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy.Neurological disorders and therapeutics targeted to surmount the blood-brain barrierGlycemic control and chronic dosing of rhesus monkeys with a fusion protein of iduronidase and a monoclonal antibody against the human insulin receptor.Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion proteinBlood-brain barrier and chemotherapeutic treatment of brain tumors.shRNA and siRNA delivery to the brainBlood-brain barrier transport of therapeutics via receptor-mediationFusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation.Polymeric nanoparticles for the drug delivery to the central nervous system.Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier.Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery.
P2860
Q21285117-C6972C90-7088-401C-9BA3-9BE5DECCF673Q24621947-60EF307D-ED4D-4121-8E03-01B71C88F449Q26745586-D16270B0-AA93-49FD-BC6B-EF9B43EF630EQ26778701-5620A9AD-B554-4BD7-B3E1-1E25DD4988C6Q28291058-155487F7-36F7-436E-9A49-7903FFB81069Q30437835-539A16FA-66B2-4A78-BD7E-DE894B5674F2Q33646512-797E5F41-60B8-454F-B088-93BFE7B45EFDQ33703457-A37C6F94-B738-4652-98CC-EC8EEB4EB6B3Q33726978-AB624EA9-0FFF-4854-A104-9FA0EC3E10DFQ33754804-079BCF8B-A865-40A7-A9BA-0FD69FDFD447Q33805709-CED6A505-B524-4A63-8010-7C51591A1B72Q33816474-76084C2B-DB0F-4A45-B9D6-71232DEBF0D8Q33827984-A626661D-AD6B-4DDA-BCF3-BF7FEDBAE680Q33948080-FB185F0F-EB7F-4667-B07E-10A377986366Q33956192-ED1009DD-A0BC-445C-B58C-B2B859B84543Q33960099-E5A2C6F0-510F-433B-BFC4-4D382D56C5FFQ34013526-EE006470-D7B2-42AD-9688-EAFFB15521B8Q34065044-2E3C1CE4-54F6-4020-9227-A0266747FA9CQ34130082-8293364B-B1F2-43EA-B786-636A3E8A8177Q34458394-35A006B2-0300-43B1-9A2D-FFCD088C7839Q35050847-D3A15DC8-BDC8-42A8-A71D-8D8FA0A25414Q35079533-6ECECE88-459C-4C5D-BFC2-AB132A4A90DEQ35161682-302AB8C9-7E8B-45E7-BFD1-AED82FF15430Q35163431-6F797C64-8DDC-49C8-9D34-F6C84D511300Q35169045-4AA8105F-6D35-42E4-ABCC-86B1F85843B7Q35169907-854725C6-B520-41BC-A686-D242E8773767Q35429973-E69B4331-1E29-49A4-9E28-18C02430DD25Q35585191-FB8666C2-62F4-451D-8A37-AAD7AD6EAB0BQ35842672-7AE8AF70-483A-42BD-9073-DD65EC796BD7Q36045429-B3E9EB5B-1084-4D86-8C62-1B0B93239CC5Q36119574-FB844C83-51FB-4E91-94EB-C48936D99665Q36296187-09884177-174F-486F-B81F-DB5162DCD9CFQ36296365-28328683-3768-4A59-89CB-23984AB2F592Q36558683-22364698-9D6D-46D5-AA89-36A8C5693A64Q36791813-6BC048C4-3451-41DD-9362-15FC606DCF9FQ36874295-F42917A1-A722-4AEE-94BB-B09A11F0C813Q37000563-46CE54B0-A696-4F81-94BE-BAB9B8A7A72CQ37076360-11FA2AA2-D7DA-4CA4-82FE-34177D856D63Q37312010-E7B9ED57-91D7-449A-90AE-F2222D0A9B5BQ37331421-2EB93B56-39C4-4821-890D-A8F2E454215B
P2860
Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@ast
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@en
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@nl
type
label
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@ast
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@en
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@nl
prefLabel
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@ast
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@en
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@nl
P2093
P921
P356
P1476
Human insulin receptor monoclo ...... arrier in vivo in the primate.
@en
P2093
P304
P356
10.1023/A:1016244500596
P577
1995-06-01T00:00:00Z