Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
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Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismSystematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activitiesDynamic structural flexibility of α-synucleinPotentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseasePropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseParkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathyPathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic miceα-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactionsPhosphorylated α-synuclein in Parkinson's disease.Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES.Phosphorylation of synucleins by members of the Polo-like kinase family.Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formationProtein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severityEvaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease.Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brainsSMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism.E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairmentParkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivoΑ-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathiesStudies of protein aggregation in A53T α-synuclein transgenic, Tg2576 transgenic, and P246L presenilin-1 knock-in cross bred mice.The A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell cultureNigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.Characterization of kinases involved in the phosphorylation of aggregated α-synuclein.Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.
P2860
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P2860
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@ast
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@en
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@nl
type
label
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@ast
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@en
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@nl
prefLabel
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@ast
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@en
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@nl
P2860
P1476
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
@en
P2093
Benoit I Giasson
Elisa A Waxman
P2860
P304
P356
10.1097/NEN.0B013E3186FC995
P577
2008-05-01T00:00:00Z