Small-molecule inducers of insulin expression in pancreatic alpha-cells. - Wikidata - awgldk - TriplyDB

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

http://www.wikidata.org/entity/Q34093859

about

β-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells Concise review: pancreas regeneration: recent advances and perspectives GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming Skin fibroblasts from patients with type 1 diabetes (T1D) can be chemically transdifferentiated into insulin-expressing clusters: a transgene-free approach Adult tissue sources for new β cells.Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK.A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.Turning straw into gold: directing cell fate for regenerative medicine.Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy.Target identification and mechanism of action in chemical biology and drug discovery.Organic synthesis toward small-molecule probes and drugs.Engineering cells with intracellular agent-loaded microparticles to control cell phenotype.Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types Making β cells from adult cells within the pancreas.Pituitary cell differentiation from stem cells and other cells: toward restorative therapy for hypopituitarism?Redifferentiation of expanded human islet β cells by inhibition of ARX.Cellular therapies based on stem cells and their insulin-producing surrogates: a 2015 reality check.New Insights into Diabetes Cell Therapy.Stress-induced adaptive islet cell identity changes Advances in β cell replacement and regeneration strategies for treating diabetes EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors.A new target for personalized medicine.3D Chemical Similarity Networks for Structure-Based Target Prediction and Scaffold Hopping.Resveratrol induces insulin gene expression in mouse pancreatic α-cells.Creating new β cells: cellular transmutation by genomic alchemy.Chemical strategies for pancreatic β cell differentiation, reprogramming, and regeneration.Chemical compound-based direct reprogramming for future clinical applications.

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P2860

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

http://www.wikidata.org/entity/Q34093859

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@ast

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@en

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@nl

type

label

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@ast

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@en

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@nl

prefLabel

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@ast

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@en

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

@nl

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PNAS.1010018107

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Small-molecule inducers of insulin expression in pancreatic alpha-cells

@en

P2093

Alykhan Shamji

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Bridget K Wagner

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Deepika Walpita

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Dina Fomina-Yadlin

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Jacob Hecksher-Sørensen

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Joshua A Bittker

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Paul A Clemons

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Stuart L Schreiber

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Tanaz Sharifnia

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Vlado Dancik

http://www.w3.org/2001/XMLSchema#string

P2860

The RSK family of kinases: emerging roles in cellular signalling

The protein kinase complement of the human genome

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

The selectivity of protein kinase inhibitors: a further update

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.

Targeting RSK: an overview of small molecule inhibitors.

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15099-15104

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107

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20696901

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