Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modificationsVACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent modelsThe proprotein convertases and their implication in sterol and/or lipid metabolismRespiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturationRole of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates.Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levelsWhat lies ahead for the proprotein convertases?Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus.Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse modelLatent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptaminePCSK5 mutation in a patient with the VACTERL association.Decreased PCSK9 expression in human hepatocellular carcinoma.Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.Opposite roles of furin and PC5A in N-cadherin processing.In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.An activin/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells.The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a).On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications.Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions.RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor.Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif.Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.Phylogenetic analysis of Amphioxus genes of the proprotein convertase family, including aPC6C, a marker of epithelial fusions during embryology.PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.An integrative genomic analysis of the superior fecundity phenotype in QSi5 mice.Thrombin activation of protein C requires prior processing by a liver proprotein convertase.Spatiotemporal expression of proprotein convertase subtilisin/kexin type 5 in the development of anorectal malformations in fetal rats.Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy
P2860
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P2860
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
description
2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Deletion of the gene encoding ...... bryonic lethality in the mouse
@ast
Deletion of the gene encoding ...... bryonic lethality in the mouse
@en
Deletion of the gene encoding ...... bryonic lethality in the mouse
@nl
type
label
Deletion of the gene encoding ...... bryonic lethality in the mouse
@ast
Deletion of the gene encoding ...... bryonic lethality in the mouse
@en
Deletion of the gene encoding ...... bryonic lethality in the mouse
@nl
prefLabel
Deletion of the gene encoding ...... bryonic lethality in the mouse
@ast
Deletion of the gene encoding ...... bryonic lethality in the mouse
@en
Deletion of the gene encoding ...... bryonic lethality in the mouse
@nl
P2093
P2860
P50
P1476
Deletion of the gene encoding ...... bryonic lethality in the mouse
@en
P2093
Ann Chamberland
Jadwiga Marcinkiewicz
Josée Hamelin
Michel Chrétien
Rachid Essalmani
P2860
P304
P356
10.1128/MCB.26.1.354-361.2006
P407
P577
2006-01-01T00:00:00Z