about
Parkin mono-ubiquitinates Bcl-2 and regulates autophagyPruning and loss of excitatory synapses by the parkin ubiquitin ligaseUbiquitin domain proteins in disease.Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.Parkin regulates translesion DNA synthesis in response to UV radiationIncreased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1)Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection.Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.A meta-analysis of the relationship of the Parkin p.Val380Leu polymorphism to Parkinson's disease.Parkin mediates the degradation-independent ubiquitination of Hsp70Mitochondrial dysfunction in genetic animal models of Parkinson's diseaseAnimal models of Parkinson's disease progressionThe parkin protein as a therapeutic target in Parkinson's disease.Regulation of the autophagic bcl-2/beclin 1 interaction.The role of parkin in familial and sporadic Parkinson's disease.Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36.Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitinationStearic acid supplementation in high protein to carbohydrate (P:C) ratio diet improves physiological and mitochondrial functions of Drosophila melanogaster parkin null mutants.Zinc supplement greatly improves the condition of parkin mutant Drosophila.Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.Linking Glycation and Glycosylation With Inflammation and Mitochondrial Dysfunction in Parkinson’s Disease.Genetics of Parkinson's disease
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Genetics of parkin-linked disease.
@ast
Genetics of parkin-linked disease.
@en
Genetics of parkin-linked disease.
@nl
type
label
Genetics of parkin-linked disease.
@ast
Genetics of parkin-linked disease.
@en
Genetics of parkin-linked disease.
@nl
prefLabel
Genetics of parkin-linked disease.
@ast
Genetics of parkin-linked disease.
@en
Genetics of parkin-linked disease.
@nl
P1433
P1476
Genetics of parkin-linked disease
@en
P2093
Nigel T Maidment
P2888
P304
P356
10.1007/S00439-003-1074-6
P577
2004-01-15T00:00:00Z
P6179
1044539710