Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
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Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastaseCharacterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domainAntithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activationSerpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functionsStructure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor proteinCrystal structure of monomeric native antithrombin reveals a novel reactive center loop conformationCrystal structure of an RNA aptamer bound to thrombinMolecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complexAn overview of the serpin superfamilyThrombin inhibition by the serpinsStructure of native protein C inhibitor provides insight into its multiple functionsC1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational diseaseHeparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal DomainStructural insight into distinct mechanisms of protease inhibition by antibodiesThe heparin binding site of protein C inhibitor is protease-dependentMolecular basis of thrombomodulin activation of slow thrombinMolecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complexStructural and Functional Characterization of a Highly Specific Serpin in the Insect Innate ImmunityStructural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1Structure-Function Analysis of Grass Clip Serine Protease Involved in Drosophila Toll Pathway ActivationHeparin binds lamprey angiotensinogen and promotes thrombin inhibition through a template mechanismA Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding ProteinsExtracellular RNA constitutes a natural procoagulant cofactor in blood coagulation.The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings.Molecular recognition mechanisms of thrombin.Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence(s).Approaches to selective peptidic inhibitors of factor Xa.Chemoenzymatic synthesis of heparin oligosaccharides with both anti-factor Xa and anti-factor IIa activities.Heparan sulfate 3-O-sulfation: a rare modification in search of a function.Understanding Dermatan Sulfate-Heparin Cofactor II Interaction through Virtual Library ScreeningHeparinoids activate a protease, secreted by mucosa and tumors, via tethering supplemented by allostery.Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa.DNA accelerates the inhibition of human cathepsin V by serpins.Serpin protease inhibitors in plant biology.Allosteric activation of antithrombin critically depends upon hinge region extension.The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.
P2860
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P2860
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@ast
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@en
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@nl
type
label
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@ast
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@en
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@nl
prefLabel
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@ast
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@en
Structure of the antithrombin- ...... rombotic mechanism of heparin.
@nl
P2093
P2860
P356
P1476
Structure of the antithrombin- ...... hrombotic mechanism of heparin
@en
P2093
Charles T Esmon
Daniel J D Johnson
James A Huntington
P2860
P2888
P304
P356
10.1038/NSMB811
P50
P577
2004-08-15T00:00:00Z