A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors.
about
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseAnesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsSize matters in activation/inhibition of ligand-gated ion channelsDecrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network modelSignal Transduction Pathways in the Pentameric Ligand-Gated Ion ChannelsAllosteric activation mechanism of the cys-loop receptorsRecent advances in Cys-loop receptor structure and functionSite-directed spin labeling reveals pentameric ligand-gated ion channel gating motionsA Structural Model of the Human α7 Nicotinic Receptor in an Open ConformationSignal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion ChannelsThe kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature.In silico models for the human alpha4beta2 nicotinic acetylcholine receptor.High throughput electrophysiology with Xenopus oocytesDisruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.Photochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation.Anesthetic binding in a pentameric ligand-gated ion channel: GLICNicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranesSubunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating.Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway.Structural answers and persistent questions about how nicotinic receptors work.An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightnessControl of ethanol sensitivity of the glycine receptor α3 subunit by transmembrane 2, the intracellular splice cassette and C-terminal domains.Contributions of conserved residues at the gating interface of glycine receptors.Isoflurane alters the structure and dynamics of GLIC.Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function.Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptorManipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofolIncompatibility between a pair of residues from the pre-M1 linker and Cys-loop blocks surface expression of the glycine receptorCharge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptorsMolecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin.A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation.Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker.Modulating inhibitory ligand-gated ion channels.Investigation of Congenital Myasthenia Reveals Functional Asymmetry of Invariant Acetylcholine Receptor (AChR) Cys-loop Aspartates.GABA(A) receptors: structure and function in the basal gangliaRoles for loop 2 residues of alpha1 glycine receptors in agonist activation.Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening.Anionic lipid and cholesterol interactions with alpha4beta2 nAChR: insights from MD simulationsLigand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain
P2860
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P2860
A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A unified view of the role of ...... gating of Cys loop receptors.
@ast
A unified view of the role of ...... gating of Cys loop receptors.
@en
A unified view of the role of ...... gating of Cys loop receptors.
@nl
type
label
A unified view of the role of ...... gating of Cys loop receptors.
@ast
A unified view of the role of ...... gating of Cys loop receptors.
@en
A unified view of the role of ...... gating of Cys loop receptors.
@nl
prefLabel
A unified view of the role of ...... gating of Cys loop receptors.
@ast
A unified view of the role of ...... gating of Cys loop receptors.
@en
A unified view of the role of ...... gating of Cys loop receptors.
@nl
P2093
P2860
P356
P1476
A unified view of the role of ...... gating of Cys loop receptors.
@en
P2093
Ariele P Hanek
Dennis A Dougherty
Henry A Lester
Jinti Wang
P2860
P304
41655-41666
P356
10.1074/JBC.M508635200
P407
P577
2005-10-10T00:00:00Z