The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.
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Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's diseasePrecocious Alterations of Brain Oscillatory Activity in Alzheimer's Disease: A Window of Opportunity for Early Diagnosis and TreatmentA γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APPOral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse ModelMT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegenerationModulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer's diseaseNonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine.Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein.Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids.Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice.Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP.Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease.Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum.Evaluation of the amyloid beta-GFP fusion protein as a model of amyloid beta peptides-mediated aggregation: a study of DNAJB6 chaperone.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stagesConcurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways.Loss of presenilin function is associated with a selective gain of APP function.Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters.Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitroDifferential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer's disease.Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?Exosomes in the Diseased Brain: First Insights from In vivo Studies.From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein.Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells.Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease.The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model.APP metabolism regulates tau proteostasis in human cerebral cortex neuronsExpression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processingPhysiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein.
P2860
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P2860
The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@ast
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@en
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@nl
type
label
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@ast
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@en
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@nl
prefLabel
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@ast
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@en
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@nl
P2093
P2860
P1476
The β-secretase-derived C-term ...... -transgenic mouse hippocampus.
@en
P2093
Charlotte Bauer
Elizabeth Brigham
Inger Lauritzen
Jean-Daniel Abraham
Julie Dunys
Ophelia Le Thuc
Paul Fraser
Peter St-George-Hyslop
Raphaëlle Pardossi-Piquard
Sébastien Ranaldi
P2860
P304
16243-1655a
P356
10.1523/JNEUROSCI.2775-12.2012
P407
P577
2012-11-01T00:00:00Z