Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder

Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder

Item
http://www.wikidata.org/entity/Q34566029
Lithium and the other mood stabilizers effective in bipolar disorder target the rat brain arachidonic acid cascadeA novel aromatic carboxylic acid inactivates luciferase by acylation of an enzymatically active regulatory lysine residue.Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.Chronic olanzapine treatment decreases arachidonic acid turnover and prostaglandin E₂ concentration in rat brain.Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats.Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans.Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4Comparative teratogenicity analysis of valnoctamide, risperidone, and olanzapine in mice.The synthesis and in vivo pharmacokinetics of fluorinated arachidonic acid: implications for imaging neuroinflammation.Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability.Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorderAnalytical approaches for lipidomics and its potential applications in neuropsychiatric disorders.The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms.Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet.Valnoctamide, which reduces rat brain arachidonic acid turnover, is a potential non-teratogenic valproate substitute to treat bipolar disorder.
P2860

Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder

Item
http://www.wikidata.org/entity/Q34566029
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@ast
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@en
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@nl
type
label
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@ast
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@en
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@nl
prefLabel
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@ast
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@en
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Valproate uncompetitively inhi ...... icacy against bipolar disorder
@en
P2093
P2860
P304
P31
P356
10.1016/J.BBALIP.2010.12.006
P407
P433
P478
P50
P577
P5875
P698
P921
P932