Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens.
about
The PD-1 pathway in tolerance and autoimmunityActive systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1Generation of Tolerogenic Dendritic Cells and Their Therapeutic ApplicationsThe PD1:PD-L1/2 Pathway from Discovery to Clinical ImplementationRegulation of T-cell Tolerance by Lymphatic Endothelial Cells.Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.Lymphatic endothelial cells - key players in regulation of tolerance and immunityChronically inflamed livers up-regulate expression of inhibitory B7 family members.B7-H1-deficiency enhances the potential of tolerogenic dendritic cells by activating CD1d-restricted type II NKT cellsYin-Yang of costimulation: crucial controls of immune tolerance and function.Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.Interplay between Inflammatory Responses and Lymphatic Vessels.LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection.Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathwayPD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice.PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosisInhibitory costimulation and anti-tumor immunity.CD28 family and chronic rejection: "to belatacept...And beyond!".T cells and T cell tumors efficiently generate antigen-specific cytotoxic T cell immunity when modified with an NKT ligandAdoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD miceDurable adoptive immunotherapy for leukemia produced by manipulation of multiple regulatory pathways of CD8+ T-cell tolerance.CD8+ T cell exhaustion during persistent viral infection is regulated independently of the virus-specific T cell receptor.Regulatory and conventional CD4+ T cells show differential effects correlating with PD-1 and B7-H1 expression after immunotherapyIntestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockadeExpression and function of PDCD1 at the human maternal-fetal interface.Regulatory T Cells Are Dispensable for Tolerance to RBC Antigens.Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection.In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit.Maternal PD-1 regulates accumulation of fetal antigen-specific CD8+ T cells in pregnancy.Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction.Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation.B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals.A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China.Molecular mechanisms of T-cell tolerance.Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse.T-cell tolerance in cancer.
P2860
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P2860
Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Cutting Edge: Programmed death ...... tolerance to tissue antigens.
@ast
Cutting Edge: Programmed death ...... tolerance to tissue antigens.
@en
Cutting Edge: Programmed death
@nl
type
label
Cutting Edge: Programmed death ...... tolerance to tissue antigens.
@ast
Cutting Edge: Programmed death ...... tolerance to tissue antigens.
@en
Cutting Edge: Programmed death
@nl
prefLabel
Cutting Edge: Programmed death ...... tolerance to tissue antigens.
@ast
Cutting Edge: Programmed death ...... tolerance to tissue antigens.
@en
Cutting Edge: Programmed death
@nl
P2093
P1476
Cutting Edge: Programmed death ...... tolerance to tissue antigens.
@en
P2093
Hideo Yagita
Natalia Martin-Orozco
Yi-Hong Wang
P304
P356
10.4049/JIMMUNOL.177.12.8291
P407
P577
2006-12-01T00:00:00Z