FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. - Wikidata - awgldk - TriplyDB

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.

http://www.wikidata.org/entity/Q34577722

about

Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human Tumorigenesis The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer From fly wings to targeted cancer therapies: a centennial for notch signaling Animal models of colorectal cancer Strategies to achieve conditional gene mutation in mice Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches Mouse models of colorectal cancer as preclinical models Dysregulation of ubiquitin ligases in cancer Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Intercellular trafficking of the nuclear oncoprotein DEK.The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer.Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer SF3B1 and other novel cancer genes in chronic lymphocytic leukemia Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients.Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.DEK over expression as an independent biomarker for poor prognosis in colorectal cancer.Roles of F-box proteins in cancer F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner Emerging roles of the FBW7 tumour suppressor in stem cell differentiation.The two faces of FBW7 in cancer drug resistance.Tumor suppressor functions of FBW7 in cancer development and progression.Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapy Stacking the DEK: from chromatin topology to cancer stem cells.miR-23a promotes the transition from indolent to invasive colorectal cancer.The prognostic potential of alternative transcript isoforms across human tumors.Study of single nucleotide polymorphisms of FBW7 and its substrate genes revealed a predictive factor for paclitaxel plus cisplatin chemotherapy in Chinese patients with advanced esophageal squamous cell carcinoma.Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation.Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain.Regulation of stem cell function by protein ubiquitylation Concise review: role of DEK in stem/progenitor cell biology Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter.Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease.Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.

P2860

Q26765153-E2E889A4-465D-49BA-A322-575FF099EC5D Q26782159-9B828243-97AC-479C-98AA-AD459699EE94 Q26783559-0AB4AB9D-E164-49E9-A7CB-2E8AE1594F71 Q27004534-CEF2C379-C067-4472-85FA-4EC5E82D0EAD Q27009170-179E40A2-8CB2-4CE0-BA42-EE6E3724E009 Q27023444-E3007C9C-C048-459C-A111-A42DE7856317 Q28077396-28C7012E-CC37-449F-9374-E51CC41E3C81 Q28081871-5B1E1BA4-EA31-4B1F-9746-9C339CA9AB1B Q28086796-7079D418-3577-4E4E-B82F-FA3E84CEF2D0 Q28658581-9BF9AE1E-8C64-4D3A-8846-121DA416DB88 Q30278581-644490B0-7823-4EB9-98C4-39473CF18D0F Q30539239-EC2830A8-5AB7-4F9D-BA94-6ED49AEFEF90 Q33720126-B4493B05-A534-441C-8648-1BFAA231EEF3 Q33789883-E0E9D835-EB3D-43A4-9955-4348068622F1 Q33976883-4776FBE7-DC98-45E7-9CBC-E7264C37D9D7 Q34093678-93C63209-B33C-4D62-8FF9-33F614385866 Q34373935-6AB20373-8D7E-4F67-8F98-8189F7E1E321 Q34488856-2DCB33C2-5A19-4BCA-8353-9D85A635F293 Q34775526-CB53BE80-2A5B-4D39-9DF7-DE3C9BC74BA0 Q34884622-5C7C972C-949A-4BCD-817E-38FB11692E04 Q35012352-BF1084D9-57DC-491E-9CCA-611659EC0EB5 Q35056718-E34D6E1E-09CB-4755-B527-CC1E82882352 Q35634693-58AEBE6D-E3A7-409B-80BA-7234CDE8D4CC Q35999467-2DA0A6B8-C8C8-4B31-8E10-6E61FB444B5F Q36025441-F8753E5F-CB79-455D-BE84-7096FB5D52F8 Q36190689-B7E65310-3E2A-41A7-9FC8-50BD8C3AD419 Q36334266-D4EC0D02-4528-46A2-9F16-EDDF0BE67A59 Q36604651-CC48A20A-240E-4E4D-8B33-20645BA59FC2 Q36837231-77D411DC-3EDA-4DFD-8C6F-4EDEAD55DFDE Q37185523-C852DD53-4BF6-4F42-BD57-84C799191322 Q37536887-591DECB0-7174-42C2-A209-60AC3761A47A Q37576259-55727297-4B1A-4B81-AD2B-CA11E1714F73 Q37694748-B758DA9C-532D-47BA-9B05-28D4220BE49E Q37707515-7ED11AA6-631A-4603-A97B-EBA5E322E31A Q38111687-D8421D67-B6D2-411B-9F10-1DF6650DDF87 Q38213913-53FAB5A7-38F9-4ABB-AEB8-C82FCA67D582 Q38315612-83BD7BCB-ACA3-4B46-A1B7-57DE0E8A83CD Q38412355-25C5538C-8803-4124-BAEF-09B33EBB8E67 Q38596749-C5054D11-9AB0-4D3E-B1DC-C2296641E4E6 Q38716109-0B573146-2FA8-4959-8469-CAF918EE0B45

P2860

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.

http://www.wikidata.org/entity/Q34577722

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@ast

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@en

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@nl

type

label

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@ast

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@en

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@nl

prefLabel

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@ast

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@en

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@nl

P1433

Q34577722-5065268C-BE84-4ACC-8F3A-4565E0B46AE1

P1476

Q34577722-56252368-2B48-458D-A417-1E8556160520

P2093

Q34577722-42EA2DBF-1637-49EA-899F-34DFAD073F65

Q34577722-493F204E-C6D7-496E-ABA1-DF4F8CE709EA

Q34577722-8088E991-2C35-42A4-A00B-50CB89902288

Q34577722-80A9B279-86F7-49D3-8D52-9105CF22628B

Q34577722-B3FA606C-F62A-4301-999A-EEE3C2B92755

Q34577722-BE5D27EC-58A0-4E78-98D9-CDAD2CB873C0

Q34577722-CEBBE0FF-0DFE-4483-B4FA-828C34F0B7FB

Q34577722-E0812292-2DAD-42E1-AA25-29E2616D91D5

Q34577722-EA9D1942-75DA-4532-9E31-F7F858FC5770

Q34577722-F3A8C1A5-DA18-4901-BC7C-8F0B12475D16

P2860

Q34577722-047C95D7-63EA-4006-9801-BE53BD88AA6B

Q34577722-049EB73F-ECBA-472A-998D-D91E026F757A

Q34577722-0F6E60CC-60A9-4FF1-9323-F51E31925392

Q34577722-13DCF04F-3685-437D-9C52-4647F29500EA

Q34577722-149DABC3-BE61-46CC-B7D2-64B9D4271724

Q34577722-17242F09-E307-4774-B849-9B9E5C8F86AF

Q34577722-1E87F135-67D6-4D15-8608-A6368316116D

Q34577722-1FE5EE4E-8AF2-499B-8D7E-33564662F6AA

Q34577722-20E511DF-21F5-45CA-B369-E53DB4F9C967

Q34577722-214728F0-F85A-4798-A2EC-C28ED0668C91

P304

Q34577722-5B873FC8-8704-4B40-BE60-15FBCD00352B

P31

Q34577722-D7A197B2-62C9-4584-A96F-01F4FE4AE836

P356

Q34577722-E8C4CDA5-7BC7-4BE6-91CE-40B6B566649F

P407

Q34577722-5DEAC619-2EE1-4561-9251-909497495868

P433

Q34577722-0F789D4C-5743-4DEA-BB94-013BB5DB63F3

P478

Q34577722-D3F943AE-C9E2-4836-BBA1-A1C81BBEBC90

P50

Q34577722-4BBC6EE6-DF8B-4DD1-BAB4-C8BFAF11F37A

Q34577722-6E917D2C-7A7F-4834-AC53-760DCAA04146

Q34577722-76AB4D02-4AA0-463E-9EE6-E2BC6E0A9AF7

Q34577722-BA640721-F4C1-476E-8BB0-BDA9DE4C3590

Q34577722-D2834E9A-E048-4805-BF76-924FD9226922

P577

Q34577722-EF67441D-84C8-40A2-ADCC-8F969356DC39

P5875

Q34577722-7EC721FD-FC5D-4D44-81DE-308D3FDBB082

P698

Q34577722-6B3A4E85-77E1-458D-94F3-E6EEB3E57BF9

P932

Q34577722-B396A85D-ABCF-4802-B156-BF3DD4CB8362

P356

P1433

Journal of Experimental Medicine

P1476

FBXW7 influences murine intest ...... Jun, and DEK for degradation.

@en

P2093

Anas Saadeddin

http://www.w3.org/2001/XMLSchema#string

Belal Muhammad

http://www.w3.org/2001/XMLSchema#string

Bradley Spencer-Dene

http://www.w3.org/2001/XMLSchema#string

ElSayed E Ibrahim

http://www.w3.org/2001/XMLSchema#string

Hayley Davis

http://www.w3.org/2001/XMLSchema#string

Mohammed Abuzinadah

http://www.w3.org/2001/XMLSchema#string

Ningning Li

http://www.w3.org/2001/XMLSchema#string

Ranjithmenon Muraleedharan

http://www.w3.org/2001/XMLSchema#string

Roya Babaei-Jadidi

http://www.w3.org/2001/XMLSchema#string

Susan Watson

http://www.w3.org/2001/XMLSchema#string

P2860

Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

Role of high-molecular weight tropomyosins in TGF-beta-mediated control of cell motility

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner

SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

The ubiquitin system

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma

P304

295-312

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1084/JEM.20100830

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

208

http://www.w3.org/2001/XMLSchema#string

P50

Annabelle Lewis

Abdolrahman Shams Nateri

P577

2011-01-31T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

49799430

http://www.w3.org/2001/XMLSchema#string

P698

21282377

http://www.w3.org/2001/XMLSchema#string

P932

3039859

http://www.w3.org/2001/XMLSchema#string