FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
about
Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human TumorigenesisThe role of the ubiquitin proteasome system in cerebellar development and medulloblastomaDissecting the Potential Interplay of DEK Functions in Inflammation and CancerFrom fly wings to targeted cancer therapies: a centennial for notch signalingAnimal models of colorectal cancerStrategies to achieve conditional gene mutation in miceWnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approachesMouse models of colorectal cancer as preclinical modelsDysregulation of ubiquitin ligases in cancerInvestigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestinesDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Intercellular trafficking of the nuclear oncoprotein DEK.The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer.Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancerSF3B1 and other novel cancer genes in chronic lymphocytic leukemiaGenomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients.Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.DEK over expression as an independent biomarker for poor prognosis in colorectal cancer.Roles of F-box proteins in cancerF-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous mannerEmerging roles of the FBW7 tumour suppressor in stem cell differentiation.The two faces of FBW7 in cancer drug resistance.Tumor suppressor functions of FBW7 in cancer development and progression.Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapyStacking the DEK: from chromatin topology to cancer stem cells.miR-23a promotes the transition from indolent to invasive colorectal cancer.The prognostic potential of alternative transcript isoforms across human tumors.Study of single nucleotide polymorphisms of FBW7 and its substrate genes revealed a predictive factor for paclitaxel plus cisplatin chemotherapy in Chinese patients with advanced esophageal squamous cell carcinoma.Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation.Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain.Regulation of stem cell function by protein ubiquitylationConcise review: role of DEK in stem/progenitor cell biologyRole of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter.Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease.Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.
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P2860
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@ast
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@en
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@nl
type
label
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@ast
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@en
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@nl
prefLabel
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@ast
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@en
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@nl
P2093
P2860
P50
P356
P1476
FBXW7 influences murine intest ...... Jun, and DEK for degradation.
@en
P2093
Anas Saadeddin
Belal Muhammad
Bradley Spencer-Dene
ElSayed E Ibrahim
Hayley Davis
Mohammed Abuzinadah
Ningning Li
Ranjithmenon Muraleedharan
Roya Babaei-Jadidi
Susan Watson
P2860
P304
P356
10.1084/JEM.20100830
P407
P577
2011-01-31T00:00:00Z