Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs.
about
Current progress and challenges in HIV gene therapyImproved knockdown from artificial microRNAs in an enhanced miR-155 backbone: a designer's guide to potent multi-target RNAiProtection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection.Optimized lentiviral vectors for HIV gene therapy: multiplexed expression of small RNAs and inclusion of MGMT(P140K) drug resistance geneSustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs.Broad-spectrum antiviral activity of RNA interference against four genotypes of Japanese encephalitis virus based on single microRNA polycistrons.RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.RNAi and small interfering RNAs in human disease therapeutic applications.Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors.Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo.RNA interference for improving the outcome of islet transplantation.Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing.Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo.Development of gene therapy for treatment of age-related macular degeneration.Multiplexing seven miRNA-Based shRNAs to suppress HIV replicationEfficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct.Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224.Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacyPreclinical evaluation of an anti-HCV miRNA cluster for treatment of HCV infectionEfficient inhibition of human immunodeficiency virus replication using novel modified microRNA-30a targeting 3'-untranslated region transcripts.Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics.Design of Effective Primary MicroRNA Mimics With Different Basal Stem Conformations.Efficient silencing of gene expression with modular trimeric Pol II expression cassettes comprising microRNA shuttles.RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs.Lentiviral delivery of short hairpin RNAsNovel HIV-1 therapeutics through targeting altered host cell pathways.RNA-interference-based gene therapy approaches to HIV type-1 treatment: tackling the hurdles from bench to bedside.Novel RNA-based strategies for therapeutic gene silencing.RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?Stable RNA interference rules for silencing.Recent advances in RNAi-based strategies for therapy and prevention of HIV-1/AIDS.A multiplexed miRNA and transgene expression platform for simultaneous repression and expression of protein coding sequences.Endogenous MCM7 microRNA cluster as a novel platform to multiplex small interfering and nucleolar RNAs for combinational HIV-1 gene therapyRegulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform.Development of hybrid baculovirus vectors for artificial MicroRNA delivery and prolonged gene suppression.A dual function TAR Decoy serves as an anti-HIV siRNA delivery vehicle.Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs.Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factorsKnockdown and replacement therapy mediated by artificial mirtrons in spinocerebellar ataxia 7.Functional VEGFA knockdown with artificial 3'-tailed mirtrons defined by 5' splice site and branch point.
P2860
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P2860
Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@ast
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@en
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@nl
type
label
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@ast
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@en
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@nl
prefLabel
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@ast
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@en
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@nl
P2093
P2860
P356
P1433
P1476
Engineering and optimization o ...... of multiplexed anti-HIV RNAs.
@en
P2093
K J von Eije
L A Aagaard
M Amarzguioui
P2860
P2888
P304
P356
10.1038/GT.2008.147
P577
2008-09-18T00:00:00Z
P5875
P6179
1009380040