Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.
about
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpointARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochoresPICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosisA conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.On the regulation, function, and localization of the DNA-dependent ATPase PICH.TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes.PICH and cotargeted Plk1 coordinately maintain prometaphase chromosome arm architecture.PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphasePICH: a DNA translocase specially adapted for processing anaphase bridge DNA.The tumor suppressor CDKN3 controls mitosis.Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAiCharacterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.Vigilance and validation: Keys to success in RNAi screening.Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interactionNovel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxelMitosis in vertebrates: the G2/M and M/A transitions and their associated checkpoints.Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis.Mitotic moonlighting functions for membrane trafficking proteinsSpindle assembly checkpoint: the third decade.Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning.PICH promotes mitotic chromosome segregation: Identification of a novel role in rDNA disjunction.Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex.Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function.ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers.SUMO-interacting motifs (SIMs) in Polo-like kinase 1-interacting checkpoint helicase (PICH) ensure proper chromosome segregation during mitosis.ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5.CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials.The equatorial position of the metaphase plate ensures symmetric cell divisionsGenome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptationALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer.Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
P2860
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P2860
Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Re-examination of siRNA specif ...... nsitive target for small RNAs.
@ast
Re-examination of siRNA specif ...... nsitive target for small RNAs.
@en
type
label
Re-examination of siRNA specif ...... nsitive target for small RNAs.
@ast
Re-examination of siRNA specif ...... nsitive target for small RNAs.
@en
prefLabel
Re-examination of siRNA specif ...... nsitive target for small RNAs.
@ast
Re-examination of siRNA specif ...... nsitive target for small RNAs.
@en
P2093
P2860
P50
P1433
P1476
Re-examination of siRNA specif ...... nsitive target for small RNAs.
@en
P2093
Nadja C Hübner
Patrick Descombes
P2860
P2888
P304
P356
10.1007/S00412-009-0244-2
P577
2009-11-11T00:00:00Z