Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains - Wikidata - awgldk - TriplyDB

Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains

Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains

http://www.wikidata.org/entity/Q35153945

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Molecular neurobiological clues to the pathogenesis of bipolar disorder Are we studying and treating schizophrenia correctly?Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients.Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes.Prenatal expression patterns of genes associated with neuropsychiatric disorders.A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.Genetic neuropathology of obsessive psychiatric syndromes.Developmental regulation of human cortex transcription and its clinical relevance at single base resolution.Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development.DNA methylation signatures in development and aging of the human prefrontal cortex.Association study between polymorphisms of the PARD3 gene and schizophrenia.Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic function.Neurodevelopmental model of schizophrenia: update 2012 Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex Postmortem human brain genomics in neuropsychiatric disorders--how far can we go?Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development.Childhood onset schizophrenia and early onset schizophrenia spectrum disorders Gene × smoking interactions on human brain gene expression: finding common mechanisms in adolescents and adults.Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study.Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia.Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?Proteomic approaches to unravel the complexity of schizophrenia.Recent genetic findings in schizophrenia and their therapeutic relevance Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies.Adult Neurogenesis and Psychiatric Disorders.Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies Expression of D-Amino Acid Oxidase (DAO/DAAO) and D-Amino Acid Oxidase Activator (DAOA/G72) during Development and Aging in the Human Post-mortem Brain.Significant association of close homologue of L1 gene polymorphism rs2272522 with schizophrenia in Qatar.Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression.Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients.A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding.Implementation and clinical characteristics of a posttraumatic stress disorder brain collection.Genetic insights into the neurodevelopmental origins of schizophrenia.Decreased white matter FA values in the left inferior frontal gyrus is a possible intermediate phenotype of schizophrenia: evidences from a novel group strategy.Genetic risk mechanisms of posttraumatic stress disorder in the human brain.Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.

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Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains

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Amanda J Law

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Barbara K Lipska

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Joel E Kleinman

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Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia

Schizophrenia: more dopamine, more D2 receptors

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia

Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia

Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia

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21183009

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