The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
about
p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumorsInsulin receptor signaling in normal and insulin-resistant statesDiverse mechanisms of AKT pathway activation in human malignancyPhosphoinositides: tiny lipids with giant impact on cell regulationMulti-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cellsThe determinants of head and neck cancer: Unmasking the PI3K pathway mutationsA systematic study of gene mutations in urothelial carcinoma; inactivating mutations in TSC2 and PIK3R1.Combined logical and data-driven models for linking signalling pathways to cellular response.PIK3R1 underexpression is an independent prognostic marker in breast cancer.p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells.Direct association of heat shock protein 20 (HSPB6) with phosphoinositide 3-kinase (PI3K) in human hepatocellular carcinoma: regulation of the PI3K activity.Identification of mutations in distinct regions of p85 alpha in urothelial cancer.PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stabilityThe Unique Non-Catalytic C-Terminus of P37delta-PI3K Adds Proliferative Properties In Vitro and In VivoAdaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancerRole of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.PIK3R1 targeting by miR-21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT, and predicts clinical outcome of breast cancer.LncRNA AK023948 is a positive regulator of AKT.STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma.Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinomaRacial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features.BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment.The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.A DNA methylation map of human cancer at single base-pair resolution.p85α is a microRNA target and affects chemosensitivity in pancreatic cancerComparing signaling networks between normal and transformed hepatocytes using discrete logical models.MicroRNA-486-5p, which is downregulated in hepatocellular carcinoma, suppresses tumor growth by targeting PIK3R1.Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity.Anti-Apoptotic Signature in Thymic Squamous Cell Carcinomas - Functional Relevance of Anti-Apoptotic BIRC3 Expression in the Thymic Carcinoma Cell Line 1889c.Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.LncRNA-mediated regulation of cell signaling in cancer.Identification of genetic disparity between primary and metastatic melanoma in human patients.Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitationThe PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.
P2860
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P2860
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
description
2010 nî lūn-bûn
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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
The phosphoinositide 3-kinase ...... on of growth factor signaling.
@ast
The phosphoinositide 3-kinase ...... on of growth factor signaling.
@en
type
label
The phosphoinositide 3-kinase ...... on of growth factor signaling.
@ast
The phosphoinositide 3-kinase ...... on of growth factor signaling.
@en
prefLabel
The phosphoinositide 3-kinase ...... on of growth factor signaling.
@ast
The phosphoinositide 3-kinase ...... on of growth factor signaling.
@en
P2093
P2860
P50
P1433
P1476
The phosphoinositide 3-kinase ...... on of growth factor signaling.
@en
P2093
Alexander R Guimaraes
Cullen M Taniguchi
Gregory Stephanopoulos
Jonathon Winnay
José O Alemán
Roderick T Bronson
Tatsuya Kondo
P2860
P304
P356
10.1158/0008-5472.CAN-09-3399
P407
P577
2010-06-08T00:00:00Z