Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow
about
Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic miceChanges in primary lymphoid organs with agingDifferential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes.Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis.Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and functionLyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.DAP12 overexpression induces osteopenia and impaired early hematopoiesis.A Kaposi's sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2Rγnull mice.Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5Aberrant antibody affinity selection in SHIP-deficient B cells.Inhibitor and activator: dual functions for SHIP in immunity and cancer.Hematopoietic cytokine-induced transcriptional regulation and Notch signaling as modulators of MDSC expansion.BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals.IL-6 blocks a discrete early step in lymphopoiesis.IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production.NF-kappaB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFalpha.SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
P2860
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P2860
Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow
description
2004 nî lūn-bûn
@nan
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
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2004年论文
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name
Src homology 2-containing 5-in ...... y myeloid cells in bone marrow
@ast
Src homology 2-containing 5-in ...... y myeloid cells in bone marrow
@en
type
label
Src homology 2-containing 5-in ...... y myeloid cells in bone marrow
@ast
Src homology 2-containing 5-in ...... y myeloid cells in bone marrow
@en
prefLabel
Src homology 2-containing 5-in ...... y myeloid cells in bone marrow
@ast
Src homology 2-containing 5-in ...... y myeloid cells in bone marrow
@en
P2093
P2860
P356
P1476
Src homology 2-containing 5-in ...... y myeloid cells in bone marrow
@en
P2093
Alexander Malykhin
K Mark Coggeshall
Kazuhiko Maeda
Koji Nakamura
Paul W Kincade
Taku Kouro
P2860
P304
P356
10.1084/JEM.20031193
P407
P577
2004-01-12T00:00:00Z