Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly
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Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus VariantsDiminished reovirus capsid stability alters disease pathogenesis and littermate transmissionStructure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution.Cleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck.Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant.Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3.A monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance.Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3.A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure.Caspase-3 activation is required for reovirus-induced encephalitis in vivo.Attenuated reovirus displays oncolysis with reduced host toxicityReovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection.Establishment of persistent infection with foot-and-mouth disease virus in BHK-21 cells.Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus.Mutating conserved cysteines in the alphavirus e2 glycoprotein causes virus-specific assembly defects.Molecular determinants of proteolytic disassembly of the reovirus outer capsid.Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64From touchdown to transcription: the reovirus cell entry pathwayReovirus receptors, cell entry, and proapoptotic signaling.The oncolytic effect in vivo of reovirus on tumour cells that have survived reovirus cell killing in vitro.Viral persistence in colorectal cancer cells infected by Newcastle disease virus.The μ1 72-96 loop controls conformational transitions during reovirus cell entry.Optimum length and flexibility of reovirus attachment protein σ1 are required for efficient viral infection.Cell entry-associated conformational changes in reovirus particles are controlled by host protease activity.Reovirus virion-like particles obtained by recoating infectious subvirion particles with baculovirus-expressed sigma3 protein: an approach for analyzing sigma3 functions during virus entry.Sites and determinants of early cleavages in the proteolytic processing pathway of reovirus surface protein sigma3.Addition of exogenous protease facilitates reovirus infection in many restrictive cells.Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis.A molecular dynamics study of reovirus attachment protein sigma1 reveals conformational changes in sigma1 structure.A plasmid-based reverse genetics system for animal double-stranded RNA viruses.JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis.
P2860
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P2860
Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly
description
1997 nî lūn-bûn
@nan
1997年の論文
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1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
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1997年论文
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1997年论文
@zh-cn
name
Reovirus variants selected dur ...... e altered in viral disassembly
@ast
Reovirus variants selected dur ...... e altered in viral disassembly
@en
type
label
Reovirus variants selected dur ...... e altered in viral disassembly
@ast
Reovirus variants selected dur ...... e altered in viral disassembly
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prefLabel
Reovirus variants selected dur ...... e altered in viral disassembly
@ast
Reovirus variants selected dur ...... e altered in viral disassembly
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P2093
P2860
P1433
P1476
Reovirus variants selected dur ...... e altered in viral disassembly
@en
P2093
G J Wilson
J D Wetzel
J P Wright
L R Dunnigan
T S Dermody
P2860
P304
P407
P577
1997-02-01T00:00:00Z