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Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivoA metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritisThe Bulk of Autotaxin Activity Is Dispensable for Adult Mouse LifeIntegrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration.Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.Non-invasive imaging of tumors by monitoring autotaxin activity using an enzyme-activated near-infrared fluorogenic substrate.Uncovering unique roles of LPA receptors in the tumor microenvironment.Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.Molecular biology of atherosclerosis.Therapeutic potentials of ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-5'-nucleotidase, and alkaline phosphatase inhibitors.Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma.Chemical modulation of glycerolipid signaling and metabolic pathways.Autotaxin inhibitors: a patent review (2012-2016).Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.Autotaxin Inhibitors May Treat Pain and Osteoarthritis.Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.Boronic Acid Group: A Cumbersome False Negative Case in the Process of Drug Design.Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Chemical evolution of autotaxin inhibitors
@ast
Chemical evolution of autotaxin inhibitors
@en
type
label
Chemical evolution of autotaxin inhibitors
@ast
Chemical evolution of autotaxin inhibitors
@en
prefLabel
Chemical evolution of autotaxin inhibitors
@ast
Chemical evolution of autotaxin inhibitors
@en
P2860
P921
P356
P1433
P1476
Chemical evolution of autotaxin inhibitors
@en
P2093
Harald M H G Albers
P2860
P304
P356
10.1021/CR2003213
P577
2012-02-15T00:00:00Z
2012-05-09T00:00:00Z