Ribosome engineering and secondary metabolite production.
about
Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutationsAntibacterial Discovery and Development: From Gene to Product and BackTime Dependency of Chemodiversity and Biosynthetic Pathways: An LC-MS Metabolomic Study of Marine-Sourced PenicilliumLaboratory-evolved mutants of an exogenous global regulator, IrrE from Deinococcus radiodurans, enhance stress tolerances of Escherichia coliImprovement of alpha-amylase production by modulation of ribosomal component protein S12 in Bacillus subtilis 168.Genome shuffling and ribosome engineering of Streptomyces actuosus for high-yield nosiheptide production.EshA accentuates ppGpp accumulation and is conditionally required for antibiotic production in Streptomyces coelicolor A3(2)Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms.Combinatorial and high-throughput screening approaches for strain engineering.Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2)Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathwayActivation of the dormant secondary metabolite production by introducing gentamicin-resistance in a marine-derived Penicillium purpurogenum G59Activation of Antibiotic Production in Bacillus spp. by Cumulative Drug Resistance Mutations.Recent advances in the discovery and development of marine microbial natural products.Disruption of rimP-SC, encoding a ribosome assembly cofactor, markedly enhances the production of several antibiotics in Streptomyces coelicolor.Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase.A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.Improvement of daptomycin production in Streptomyces roseosporus through the acquisition of pleuromutilin resistance.Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetesIdentification of two novel anti-fibrotic benzopyran compounds produced by engineered strains derived from Streptomyces xiamenensis M1-94P that originated from deep-sea sediments.Activation of dormant secondary metabolism neotrehalosadiamine synthesis by an RNA polymerase mutation in Bacillus subtilis.New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters.Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements.Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.An overview of rapamycin: from discovery to future perspectives.Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.Rare Chromones from a Fungal Mutant of the Marine-Derived Penicillium purpurogenum G59.Activation of the silent secondary metabolite production by introducing neomycin-resistance in a marine-derived Penicillium purpurogenum G59.Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules.Activation of dormant secondary metabolite production by introducing neomycin resistance into the deep-sea fungus, Aspergillus versicolor ZBY-3.Antibiotic biosynthesis following horizontal gene transfer: new milestone for novel natural product discovery?Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans.An insight into the "-omics" based engineering of streptomycetes for secondary metabolite overproduction.Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6'-deoxy-bleomycin Z production.Strategies to diversify natural products for drug discovery.Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines.Characterization of representative rpoB gene mutations leading to a significant change in toyocamycin production of Streptomyces diastatochromogenes 1628.
P2860
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P2860
Ribosome engineering and secondary metabolite production.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Ribosome engineering and secondary metabolite production.
@ast
Ribosome engineering and secondary metabolite production.
@en
type
label
Ribosome engineering and secondary metabolite production.
@ast
Ribosome engineering and secondary metabolite production.
@en
prefLabel
Ribosome engineering and secondary metabolite production.
@ast
Ribosome engineering and secondary metabolite production.
@en
P2093
P1476
Ribosome engineering and secondary metabolite production.
@en
P2093
Kazuhiko Kurosawa
Susumu Okamoto
Takashi Inaoka
Takeshi Hosaka
Yuzuru Tozawa
P304
P356
10.1016/S0065-2164(04)56005-7
P577
2004-01-01T00:00:00Z