Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
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DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancerPI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.FAM83A confers EGFR-TKI resistance in breast cancer cells and in miceDACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growthAdiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1Unraveling the microenvironmental influences on the normal mammary gland and breast cancerNetwork analysis of breast cancer progression and reversal using a tree-evolving network algorithmOf extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroidsc-Src-mediated epithelial cell migration and invasion regulated by PDZ binding site.Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins.Three-dimensional culture models of normal and malignant breast epithelial cells.Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging.Adhesion shapes T cells for prompt and sustained T-cell receptor signalling.Coherent angular motion in the establishment of multicellular architecture of glandular tissues.Regulation of the basement membrane by epithelia generated forces.Three-dimensional culturing of the Hodgkin lymphoma cell-line L1236 induces a HL tissue-like gene expression pattern.A new tumor suppressor that regulates tissue architecture.Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice.c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cellsRap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells.Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress.Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivoBiomechanical approaches for studying integration of tissue structure and function in mammary epithelia.Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformationContext, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment.RORα suppresses breast tumor invasion by inducing SEMA3F expressionThe need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancerIncreased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathwaysDepletion of nuclear actin is a key mediator of quiescence in epithelial cells.Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo.Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes.Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.Disruption of 3D MCF-12A breast cell cultures by estrogens--an in vitro model for ER-mediated changes indicative of hormonal carcinogenesis.Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane
P2860
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P2860
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Polarity and proliferation are ...... breast epithelial tumor cells
@ast
Polarity and proliferation are ...... breast epithelial tumor cells
@en
type
label
Polarity and proliferation are ...... breast epithelial tumor cells
@ast
Polarity and proliferation are ...... breast epithelial tumor cells
@en
prefLabel
Polarity and proliferation are ...... breast epithelial tumor cells
@ast
Polarity and proliferation are ...... breast epithelial tumor cells
@en
P2093
P2860
P356
P1476
Polarity and proliferation are ...... breast epithelial tumor cells
@en
P2093
Derek C Radisky
Mina J Bissell
P2860
P304
P356
10.1083/JCB.200306090
P407
P577
2004-02-09T00:00:00Z