Caenorhabditis elegans UNC-45 is a component of muscle thick filaments and colocalizes with myosin heavy chain B, but not myosin heavy chain A
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Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motilityMyosin chaperonesThe Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegansDistinctive genes determine different intramuscular fat and muscle fiber ratios of the longissimus dorsi muscles in Jinhua and landrace pigsUnc45 activates Hsp90-dependent folding of the myosin motor domainUnc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domainLack of developmental redundancy between Unc45 proteins in zebrafish muscle developmentKnockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos.Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegansGetting folded: chaperone proteins in muscle development, maintenance and disease.The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataractThe UNC-45 myosin chaperone: from worms to flies to vertebrates.Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability.A region of the myosin rod important for interaction with paramyosin in Caenorhabditis elegans striated muscle.The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegansInvertebrate muscles: muscle specific genes and proteins.Still Heart Encodes a Structural HMT, SMYD1b, with Chaperone-Like Function during Fast Muscle Sarcomere Assembly.Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight musclesUCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells.Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibrilLoss of unc45a precipitates arteriovenous shunting in the aortic arches.Invertebrate muscles: thin and thick filament structure; molecular basis of contraction and its regulation, catch and asynchronous muscle.She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae.Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival.Translation readthrough mitigation.At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis.Chaperoning myosin assembly in muscle formation and aging.Myosin assembly, maintenance and degradation in muscle: Role of the chaperone UNC-45 in myosin thick filament dynamics.UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM.UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.A zebrafish unc-45-related gene expressed during muscle development.Loss-of-Function Mutations in UNC45A Cause a Syndrome Associating Cholestasis, Diarrhea, Impaired Hearing, and Bone Fragility.Cloning, molecular characterization, and expression analysis of the unc45 myosin chaperone b(unc45b)gene of grass carp (Ctenopharyngodon idellus).
P2860
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P2860
Caenorhabditis elegans UNC-45 is a component of muscle thick filaments and colocalizes with myosin heavy chain B, but not myosin heavy chain A
description
2000 nî lūn-bûn
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name
Caenorhabditis elegans UNC-45 ...... , but not myosin heavy chain A
@ast
Caenorhabditis elegans UNC-45 ...... , but not myosin heavy chain A
@en
type
label
Caenorhabditis elegans UNC-45 ...... , but not myosin heavy chain A
@ast
Caenorhabditis elegans UNC-45 ...... , but not myosin heavy chain A
@en
prefLabel
Caenorhabditis elegans UNC-45 ...... , but not myosin heavy chain A
@ast
Caenorhabditis elegans UNC-45 ...... , but not myosin heavy chain A
@en
P2860
P356
P1476
Caenorhabditis elegans UNC-45 ...... , but not myosin heavy chain A
@en
P2860
P304
P356
10.1083/JCB.148.2.375
P407
P577
2000-01-01T00:00:00Z