Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.
about
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signalingExpression of Mad1 in T cells leads to reduced thymic cellularity and impaired mitogen-induced proliferationLineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.Elimination of CD8+ thymocytes in transgenic mice expressing an anti-Lyt2.2 immunoglobulin heavy chain gene.Organ injury associated with extrathymic induction of immune tolerance in doubly transgenic mice.Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.Self-reactive T cells can escape clonal deletion in T-cell receptor V beta 8.1 transgenic mice.T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection.HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells.Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene.Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor.Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease.Development of the CD4 and CD8 lineage of T cells: instruction versus selection.Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules.Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.An unusual lineage of alpha/beta T cells that contains autoreactive cells.CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.Distinctive selection mechanisms govern the T cell receptor repertoire of peripheral CD4-CD8- alpha/beta T cells.Induction of tolerance to autoimmune diabetes with islet antigens.CD45RA and CD45RBhigh expression induced by thymic selection eventsCD8 is required during positive selection of CD4-/CD8+ T cellsTransgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4-CD8-B220+ T cells in lpr/lpr miceMajor histocompatibility complex-specific prolongation of murine skin and cardiac allograft survival after in vivo depletion of V beta+ T cellsHigh- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytesThe T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.Modulation of T cell development by an endogenous altered peptide ligandT cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.Critical role for the common cytokine receptor gamma chain in intrathymic and peripheral T cell selectionInhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cellsRequirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selectionPremature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells.A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire.Role of different T cell receptors in the development of pre-T cells.Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response.An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes.Positive selection of extrathymically developed T cells by self-antigens
P2860
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P2860
Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Deletion of autospecific T cel ...... d low levels of CD8 molecules.
@ast
Deletion of autospecific T cel ...... d low levels of CD8 molecules.
@en
type
label
Deletion of autospecific T cel ...... d low levels of CD8 molecules.
@ast
Deletion of autospecific T cel ...... d low levels of CD8 molecules.
@en
prefLabel
Deletion of autospecific T cel ...... d low levels of CD8 molecules.
@ast
Deletion of autospecific T cel ...... d low levels of CD8 molecules.
@en
P2093
P2860
P356
P1476
Deletion of autospecific T cel ...... d low levels of CD8 molecules.
@en
P2093
P2860
P304
P356
10.1084/JEM.169.3.795
P407
P577
1989-03-01T00:00:00Z