Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells
about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerAn overview of Cdk1-controlled targets and processesThe role of heterochromatin in centromere functionLoss of pRB causes centromere dysfunction and chromosomal instabilityGenome stability is ensured by temporal control of kinetochore-microtubule dynamicsHuman centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathwayChromosomal variation in neurons of the developing and adult mammalian nervous systemMicrotubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochoresLethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.Chromosomal instability and cancer: a complex relationship with therapeutic potentialCytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivationThe centromere geometry essential for keeping mitosis error free is controlled by spindle forcesWhen 2+2=5: the origins and fates of aneuploid and tetraploid cellshNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cellsNercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progressionBorealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindleHere, there, and everywhere: kinetochore function on holocentric chromosomesOocyte Maturation and DevelopmentSomatic mosaicism in the human genomeDNA damage associated with mitosis and cytokinesis failureCell division: control of the chromosomal passenger complex in time and spaceChromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomesBasic mechanism for biorientation of mitotic chromosomes is provided by the kinetochore geometry and indiscriminate turnover of kinetochore microtubules.Laser microsurgery reveals conserved viscoelastic behavior of the kinetochore.Polyploids require Bik1 for kinetochore-microtubule attachment.Transcriptional control of mitosis: deregulation and cancerDepletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachmentsA screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defectBrd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatinCDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following MitosisA mechanism linking extra centrosomes to chromosomal instabilityA Centromere-Signaling Network Underlies the Coordination among Mitotic EventsHeterogeneous architecture of vertebrate kinetochores revealed by three-dimensional superresolution fluorescence microscopy.The mitotic origin of chromosomal instability.Protein architecture of the human kinetochore microtubule attachment site.The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.Chromosome malorientations after meiosis II arrest cause nondisjunctionEarly aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.Examining the link between chromosomal instability and aneuploidy in human cellsThe spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes.
P2860
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P2860
Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Merotelic kinetochore orientat ...... mitotic mammalian tissue cells
@ast
Merotelic kinetochore orientat ...... mitotic mammalian tissue cells
@en
type
label
Merotelic kinetochore orientat ...... mitotic mammalian tissue cells
@ast
Merotelic kinetochore orientat ...... mitotic mammalian tissue cells
@en
prefLabel
Merotelic kinetochore orientat ...... mitotic mammalian tissue cells
@ast
Merotelic kinetochore orientat ...... mitotic mammalian tissue cells
@en
P2093
P2860
P356
P1476
Merotelic kinetochore orientat ...... mitotic mammalian tissue cells
@en
P2093
P2860
P304
P356
10.1083/JCB.153.3.517
P407
P577
2001-04-01T00:00:00Z