Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells - Wikidata - awgldk - TriplyDB

Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

http://www.wikidata.org/entity/Q36360359

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer An overview of Cdk1-controlled targets and processes The role of heterochromatin in centromere function Loss of pRB causes centromere dysfunction and chromosomal instability Genome stability is ensured by temporal control of kinetochore-microtubule dynamics Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway Chromosomal variation in neurons of the developing and adult mammalian nervous system Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.Chromosomal instability and cancer: a complex relationship with therapeutic potential Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation The centromere geometry essential for keeping mitosis error free is controlled by spindle forces When 2+2=5: the origins and fates of aneuploid and tetraploid cells hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle Here, there, and everywhere: kinetochore function on holocentric chromosomes Oocyte Maturation and Development Somatic mosaicism in the human genome DNA damage associated with mitosis and cytokinesis failure Cell division: control of the chromosomal passenger complex in time and space Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes Basic mechanism for biorientation of mitotic chromosomes is provided by the kinetochore geometry and indiscriminate turnover of kinetochore microtubules.Laser microsurgery reveals conserved viscoelastic behavior of the kinetochore.Polyploids require Bik1 for kinetochore-microtubule attachment.Transcriptional control of mitosis: deregulation and cancer Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis A mechanism linking extra centrosomes to chromosomal instability A Centromere-Signaling Network Underlies the Coordination among Mitotic Events Heterogeneous architecture of vertebrate kinetochores revealed by three-dimensional superresolution fluorescence microscopy.The mitotic origin of chromosomal instability.Protein architecture of the human kinetochore microtubule attachment site.The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.Chromosome malorientations after meiosis II arrest cause nondisjunction Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.Examining the link between chromosomal instability and aneuploidy in human cells The spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes.

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Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

http://www.wikidata.org/entity/Q36360359

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2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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Merotelic kinetochore orientat ...... mitotic mammalian tissue cells

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Merotelic kinetochore orientat ...... mitotic mammalian tissue cells

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Merotelic kinetochore orientat ...... mitotic mammalian tissue cells

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Journal of Cell Biology

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Merotelic kinetochore orientat ...... mitotic mammalian tissue cells

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P2093

A Khodjakov

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B Howell

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E D Salmon

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F Degrassi

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P2860

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis

Genetic instability of cancer cells is proportional to their degree of aneuploidy

Kinetochore fiber maturation in PtK1 cells and its implications for the mechanisms of chromosome congression and anaphase onset

Genetic instabilities in human cancers

How cells get the right chromosomes

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

Functional redundancy in the maize meiotic kinetochore

Differential expression of a phosphoepitope at the kinetochores of moving chromosomes

Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane).

The kinetochore of higher eucaryotes: a molecular view.

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