FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia. - Wikidata - awgldk - TriplyDB

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

http://www.wikidata.org/entity/Q36407239

about

Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Modeling interactions between leukemia-specific chromosomal changes, somatic mutations, and gene expression patterns during progression of core-binding factor leukemias Prognostic value of FLT3 mutations among different cytogenetic subgroups in acute myeloid leukemia.Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner.Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia Mechanisms of resistance to FLT3 inhibitors.Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia.Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects.Mouse models for core binding factor leukemia.Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.Telomerase reverse transcriptase (TERT) A1062T mutation as a prognostic factor in Egyptian patients with acute myeloid leukemia (AML).Leukemogenic potency of the novel FLT3-N676K mutant.CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice.Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice Myeloid neoplasms with concurrent BCR-ABL1 and CBFB rearrangements: A series of 10 cases of a clinically aggressive neoplasm.Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia.

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P2860

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

http://www.wikidata.org/entity/Q36407239

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年学术文章

@wuu

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

2007年學術文章

@zh

2007年學術文章

@zh-hant

name

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

@ast

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

@en

type

label

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

@ast

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

@en

prefLabel

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

@ast

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

@en

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P1476

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia

@en

P2093

C Scott Swindle

http://www.w3.org/2001/XMLSchema#string

Christopher A Klug

http://www.w3.org/2001/XMLSchema#string

Claudiu V Cotta

http://www.w3.org/2001/XMLSchema#string

Hyung-Gyoon Kim

http://www.w3.org/2001/XMLSchema#string

Kyoko Kojima

http://www.w3.org/2001/XMLSchema#string

Yongliang Huo

http://www.w3.org/2001/XMLSchema#string

P2860

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

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1567-1574

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scholarly article

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10.1182/BLOOD-2006-06-030312

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3

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Vishnu V B Reddy

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2007-10-29T00:00:00Z

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5878213

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17967943

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2214774

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