Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.
about
Elusive roles for reactive astrocytes in neurodegenerative diseasesAutophagy in the physiology and pathology of the central nervous systemROS and brain diseases: the good, the bad, and the uglyAdaptive regulation of the brain's antioxidant defences by neurons and astrocytesNRF2-regulation in brain health and disease: implication of cerebral inflammationRole of the Keap1/Nrf2 pathway in neurodegenerative diseases.Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagyNRF2 promotes neuronal survival in neurodegeneration and acute nerve damage.Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases.Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's DiseaseIn vivo astrocytic Ca(2+) signaling in health and brain disorders.Recent advances in autophagy-based neuroprotection.Astrocytes in neurodegenerative disease.Microglia antioxidant systems and redox signalling.Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms.Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction.Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders.Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer's Disease?Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.Simvastatin as a Potential Disease-Modifying Therapy for Patients with Parkinson's Disease: Rationale for Clinical Trial, and Current Progress.Diversity of astroglial responses across human neurodegenerative disorders and brain aging.Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence.Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusionMicroglia Response During Parkinson's Disease: Alpha-Synuclein Intervention
P2860
Q26797399-F348D125-5D28-4A17-9762-7D847813D060Q27000701-60EC808F-9D9A-47B6-BB09-E5FB238B396BQ27014070-8CD1DD35-C3AD-4DE4-AAC1-B661DCA88B72Q28074104-F69395AB-9748-4C5B-ABD8-7BD96132C040Q28397785-A9AB266F-74FD-43CA-97C6-6AEB7FBE1BA2Q34464138-1226A86B-CCD1-4C25-8569-0E50AB1FACA1Q35044490-96EE677D-C8DE-409B-BF13-6BA28D414E63Q35408649-0F230F0C-BE6A-4EB7-8F38-488C9CEA9BCEQ36100277-C802B73B-4E36-4A9D-A5AE-185B664A41F8Q36622182-937DA94E-0BA2-4D9C-870F-00B664A6B03EQ36722167-B3F837E7-128E-466D-973A-6CA497597776Q36732766-5F3FEC56-B6C5-4653-BF8D-2A27EC9C51A1Q37091371-5100B497-4BDC-4697-99DB-4EFA1D78556EQ37414788-8E6E3E28-A5B8-4FD5-965D-1358BB5621D4Q38329808-82F66783-6E07-4929-9AE4-DABD4B0360D0Q38422519-A2899CF3-6637-481A-A61C-75EDA5CE5BF9Q38692790-E108AFD6-440F-45DF-AEA3-AEFD8B9F4CBBQ38715902-69CFDD1E-D5A5-4590-A6CE-D27A26C78B7CQ39033667-A0F5DDB3-ABB8-4296-B28A-1A010ED4B07FQ39181656-CE1D7C1C-B35F-4831-A4A9-FCBC26223CE8Q39340496-B931DF80-8FD9-4833-B657-DBC75206134DQ41575678-797B7AD3-AC58-451C-9DE8-27A03F2D73A6Q41662736-94E00D9B-9A21-4515-96A9-A2255F4B49A0Q41827284-DC8B3049-7D88-4C7D-9EB7-342263819AF6Q42288817-D6742E90-40A0-4140-99BD-3623E761C6ADQ45201060-3ED70ABC-1603-4EEC-A205-3C13220DDF34Q47929663-64D7456C-D7CC-4AF9-9D2F-F6E4468F702BQ50531054-2B0A58DE-92D5-4D8A-959E-82FE7982628DQ51767721-B51EB7DF-FBD4-4574-8891-84396CCB2A03Q58722127-7CB2D5FE-CE4A-49CE-9311-471BB939AAD2Q58799080-299E5E1E-2055-47ED-A8F3-9D8846750DF4
P2860
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Astrocyte-specific overexpress ...... ein mutant (A53T) mouse model.
@ast
Astrocyte-specific overexpress ...... ein mutant (A53T) mouse model.
@en
type
label
Astrocyte-specific overexpress ...... ein mutant (A53T) mouse model.
@ast
Astrocyte-specific overexpress ...... ein mutant (A53T) mouse model.
@en
prefLabel
Astrocyte-specific overexpress ...... ein mutant (A53T) mouse model.
@ast
Astrocyte-specific overexpress ...... ein mutant (A53T) mouse model.
@en
P2093
P2860
P921
P1476
Astrocyte-specific overexpress ...... ein mutant (A53T) mouse model.
@en
P2093
Delinda A Johnson
Jeffrey A Johnson
Marcelo R Vargas
P2860
P304
17775-17787
P356
10.1523/JNEUROSCI.3049-12.2012
P407
P577
2012-12-01T00:00:00Z