Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. - Wikidata - awgldk - TriplyDB

Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

http://www.wikidata.org/entity/Q36540639

about

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1 Nuclear receptor coregulators: modulators of pathology and therapeutic targets Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology The 19 s proteasome subcomplex establishes a specific protein interaction network at the promoter for stimulated transcriptional initiation in vivo.SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein Disruption of histone modification and CARM1 recruitment by arsenic represses transcription at glucocorticoid receptor-regulated promoters.Quantitative proteome analysis of the 20S proteasome of apoptotic Jurkat T cells.The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis.Global characterization of transcriptional impact of the SRC-3 coregulator Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus.Nuclear receptor coactivators: master regulators of human health and disease.Ligand-dependent degradation of SRC-1 is pivotal for progesterone receptor transcriptional activity.miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65.The role of AIB1 in breast cancer Derailed estrogen signaling and breast cancer: an authentic couple.Steroid receptor coactivator-3 as a potential molecular target for cancer therapy.Nuclear receptor coactivators: structural and functional biochemistry.Cracking the coregulator codes.The "fourth dimension" of gene transcription.Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity Multi-modulation of nuclear receptor coactivators through posttranslational modifications Par complex in cancer: a regulator of normal cell polarity joins the dark side.Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy.Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.Steroid receptor coactivator (SRC) family: masters of systems biology.Apicobasal polarity and cell proliferation during development.Proteins directly interacting with mammalian 20S proteasomal subunits and ubiquitin-independent proteasomal degradation cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1 Analysis of the human endogenous coregulator complexome.CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.The DNA damage response pathway regulates the alternative splicing of the apoptotic mediator Bcl-x.Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression.Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.Overexpression of sigma-1 receptor in MCF-7 cells enhances proliferation via the classic protein kinase C subtype signaling pathway Protein Kinase C (PKC) Isozymes and Cancer

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P2860

Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

http://www.wikidata.org/entity/Q36540639

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

@zh-cn

name

Atypical protein kinase C regu ...... ogenic coactivator SRC-3/AIB1.

@ast

Atypical protein kinase C regu ...... ogenic coactivator SRC-3/AIB1.

@en

type

label

Atypical protein kinase C regu ...... ogenic coactivator SRC-3/AIB1.

@ast

Atypical protein kinase C regu ...... ogenic coactivator SRC-3/AIB1.

@en

prefLabel

Atypical protein kinase C regu ...... ogenic coactivator SRC-3/AIB1.

@ast

Atypical protein kinase C regu ...... ogenic coactivator SRC-3/AIB1.

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P356

J.MOLCEL.2007.12.030

P1433

P1476

Atypical protein kinase C regu ...... ogenic coactivator SRC-3/AIB1.

@en

P2093

David M Lonard

http://www.w3.org/2001/XMLSchema#string

Larbi Amazit

http://www.w3.org/2001/XMLSchema#string

Ming-Jer Tsai

http://www.w3.org/2001/XMLSchema#string

Ping Yi

http://www.w3.org/2001/XMLSchema#string

Qin Feng

http://www.w3.org/2001/XMLSchema#string

Sophia Y Tsai

http://www.w3.org/2001/XMLSchema#string

P2860

The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome

P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators

Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7

Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

Transcription factor-specific requirements for coactivators and their acetyltransferase functions

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development

The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation.

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465-476

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scholarly article

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10.1016/J.MOLCEL.2007.12.030

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4

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29

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Bert W. O'Malley

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2008-02-01T00:00:00Z

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5539736

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18313384

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2293272

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