Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.
about
Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiationCytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteinsRegulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinaseLamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma proteinc-Abl is required for development and optimal cell proliferation in the context of p53 deficiencyNuclear-cytoplasmic shuttling of C-ABL tyrosine kinaseInhibition of c-Abl tyrosine kinase activity by filamentous actin.Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck.Abl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin.Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket.Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL.Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress.Persistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine.Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disordersIdentification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II.Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylationIncreased sensitivity to apoptotic stimuli in c-abl-deficient progenitor B-cell linesInduction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling.Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport.Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function.Binding of A/T-rich DNA by three high mobility group-like domains in c-Abl tyrosine kinase.An activating mutation in the ATP binding site of the ABL kinase domain.Delineation of key regulatory elements identifies points of vulnerability in the mitogen-activated signaling network.Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other.The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectin.Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product.c-abl is involved in the association of p53 and trk A.Growth inhibition by Abl requires an interplay of its SH2 and tyrosine kinase domains.Antagonistic effects of ABL and BCRABL proteins on proliferation and the response to genotoxic stress in normal and leukemic myeloid cells.Bcr-Abl-mediated resistance to apoptosis is independent of constant tyrosine-kinase activity.Reduction of apoptosis in Rb-deficient embryos via Abl knockout.Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function.Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells.Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.Dominant effects of the bcr-abl oncogene on Drosophila morphogenesis.
P2860
Q24298312-D6AFB7F7-8CB2-427C-8BBB-01E9F79F6B0FQ24316283-D2E4B34F-7EC1-48F4-A3C4-642CA9F969B5Q24320206-739082B9-FF0B-4F78-B1B3-C1A0613608F0Q24541561-B411111D-94F8-4566-8E97-CAD96A5D890EQ28511871-5C18164F-1772-496E-B938-1172A72FE851Q28591266-A075599C-6C8F-40E1-AD1F-8A706569DE14Q30168272-D261CD81-88A8-4F0C-8517-7292C586379FQ30175353-93773A65-C120-4B95-9072-A92054CA0374Q30444235-5FD9E9FE-8D0E-4ED8-BA8D-2F167D3356A7Q33774923-405883F1-4C4A-454B-BD2B-B0FEC63EC72CQ33828334-DB6386D9-059E-4ACC-93AB-EC9D9932DBCEQ34029064-A600810E-D6AF-4EE5-A4C7-FFCC88D63889Q35023172-B621F213-E9DE-4E3B-9F86-AECA6B6D1F7AQ36374813-BFD4D5BF-8B77-40EC-A393-C112423155CBQ36560556-41748806-5C20-4D3D-827F-DA4F344F5C84Q36573000-DB5BE48B-F3AD-4B70-B296-4059C034A58FQ36688513-5C251714-96B2-495E-90A8-E8AC578AE180Q36972619-24B90773-D501-4ED4-B1CD-6C4E7EFC7212Q37087928-3BD40399-5035-407C-8A45-4A1DD2953F2EQ38103250-380B41D0-A433-4440-8011-C2F5BA1A13DFQ38353121-E40FAE96-288B-4CD1-858F-B1A2274195BAQ38354181-5BE9AA7F-E0C6-436E-B7BF-0CC931E17CE5Q39475720-DB1C642A-BDFE-4017-8411-4CA9D6731ED4Q39882060-E6838E53-DA8E-4D35-99B9-E0AE2FC13346Q41751646-780DE385-59FF-4718-AE6A-ADA7E277186AQ42441560-4A6E04DE-CAA0-41D0-A4C1-0C1CE536B25BQ42800244-EA104957-4AEC-49D6-9E26-2298149070FCQ42810871-FBB76E0E-CF48-41D3-BCC0-D3C511E94869Q44401305-453DC822-D025-4B29-9114-F982C0A42A46Q44427680-028967D1-5453-4741-9E56-56CA9F446FAFQ44732794-1AD65BDA-B379-4187-9A57-342E6DB90898Q45177408-53F10B75-24E5-471A-B883-57D360BA670AQ47761529-89D9EB49-411E-4940-949C-C00688F0A38DQ51988173-C355B1F5-4438-4F13-B38B-4D0D736455E1Q52568060-20B2A513-4040-4A7B-A971-87931502D777
P2860
Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Abrogation of retinoblastoma p ...... t and -independent mechanisms.
@ast
Abrogation of retinoblastoma p ...... t and -independent mechanisms.
@en
type
label
Abrogation of retinoblastoma p ...... t and -independent mechanisms.
@ast
Abrogation of retinoblastoma p ...... t and -independent mechanisms.
@en
prefLabel
Abrogation of retinoblastoma p ...... t and -independent mechanisms.
@ast
Abrogation of retinoblastoma p ...... t and -independent mechanisms.
@en
P2860
P356
P1476
Abrogation of retinoblastoma p ...... t and -independent mechanisms.
@en
P2093
P2860
P304
P356
10.1128/MCB.15.10.5542
P407
P577
1995-10-01T00:00:00Z