A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity.
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TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosisMutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALSConjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUSDysregulated axonal RNA translation in amyotrophic lateral sclerosisImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationPathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersYeast prions and human prion-like proteins: sequence features and prediction methodsDoes a loss of TDP-43 function cause neurodegeneration?Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegansEssential genetic interactors of SIR2 required for spatial sequestration and asymmetrical inheritance of protein aggregatesHyperphosphorylation as a defense mechanism to reduce TDP-43 aggregationTDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegansTDP-43 aggregation in neurodegeneration: are stress granules the key?The neurogenetics of alternative splicingEngineering enhanced protein disaggregases for neurodegenerative diseaseTDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degenerationALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusionsGTPase activity plays a key role in the pathobiology of LRRK2.Modeling Huntington disease in yeast: perspectives and future directions.Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.RNA metabolism in neurodegenerative disease.Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismThe role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia.Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLSA yeast model of FUS/TLS-dependent cytotoxicity.TAR DNA-binding protein 43 in neurodegenerative disease.Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.High-throughput yeast plasmid overexpression screenNeurotoxic effects of TDP-43 overexpression in C. elegans.Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatmentAltered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragmentsThe aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila.Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
P2860
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P2860
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
A yeast TDP-43 proteinopathy m ...... egation and cellular toxicity.
@ast
A yeast TDP-43 proteinopathy m ...... egation and cellular toxicity.
@en
type
label
A yeast TDP-43 proteinopathy m ...... egation and cellular toxicity.
@ast
A yeast TDP-43 proteinopathy m ...... egation and cellular toxicity.
@en
prefLabel
A yeast TDP-43 proteinopathy m ...... egation and cellular toxicity.
@ast
A yeast TDP-43 proteinopathy m ...... egation and cellular toxicity.
@en
P2093
P2860
P356
P1476
A yeast TDP-43 proteinopathy m ...... egation and cellular toxicity.
@en
P2093
Aaron D Gitler
Brian S Johnson
J Michael McCaffery
P2860
P304
P356
10.1073/PNAS.0802082105
P407
P577
2008-04-23T00:00:00Z