Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression.
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MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin geneIdentification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expressionINS-gene mutations: from genetics and beta cell biology to clinical diseaseIsolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expressionGlucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localizationInvolvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cellsRegulation of the insulin gene by glucose and fatty acidsRecessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene.Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expressionIslet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.MAFA controls genes implicated in insulin biosynthesis and secretionMafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3.Short-term regulation of insulin gene transcription by glucose.A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured isletsc-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene productsFunctional characterization of the transactivation properties of the PDX-1 homeodomain protein.A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cellsp38 MAPK is a major regulator of MafA protein stability under oxidative stress.Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Stem cell therapy for type 1 diabetes mellitus.MafA and MafB activity in pancreatic β cells.Gene-specific transcriptional activity of the insulin cAMP-responsive element is conferred by NF-Y in combination with cAMP response element-binding protein.Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells.Role of pancreatic transcription factors in maintenance of mature β-cell function.Appropriate therapy for type 2 diabetes mellitus in view of pancreatic β-cell glucose toxicity: "the earlier, the better".Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cellsPreferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.Regulation of insulin gene transcription by multiple histone acetyltransferases.Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology.Prolactin regulatory element binding protein as a potential transcriptional factor for the insulin gene in response to glucose stimulation.Regulation of insulin gene expression by overlapping DNA-binding elements.The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose.Glucose regulates insulin gene transcription by hyperacetylation of histone h4.The DNA binding activity of the RIPE3b1 transcription factor of insulin appears to be influenced by tyrosine phosphorylation.
P2860
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P2860
Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Glucose-induced transcription ...... cell-type-specific expression.
@ast
Glucose-induced transcription ...... cell-type-specific expression.
@en
type
label
Glucose-induced transcription ...... cell-type-specific expression.
@ast
Glucose-induced transcription ...... cell-type-specific expression.
@en
prefLabel
Glucose-induced transcription ...... cell-type-specific expression.
@ast
Glucose-induced transcription ...... cell-type-specific expression.
@en
P2860
P356
P1476
Glucose-induced transcription ...... cell-type-specific expression.
@en
P2093
P2860
P304
P356
10.1128/MCB.14.2.871
P407
P577
1994-02-01T00:00:00Z