Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.
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Insulin-secreting β cells require a post-genomic conceptRecent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem CellsAdvances and challenges in the differentiation of pluripotent stem cells into pancreatic β cellsPancreatic stem cells remain unresolvedCurrent stem cell based therapies in diabetesThe cell cycle as a brake for β-cell regeneration from embryonic stem cellsGeneration of functional human pancreatic β cells in vitroHuman pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.FunPat: function-based pattern analysis on RNA-seq time series data.Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitroEfficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations.Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors.Human pancreatic beta-like cells converted from fibroblasts.Revealing transcription factors during human pancreatic β cell development.Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells.Epigenetics and type II diabetes mellitus: underlying mechanisms of prenatal predispositionChromatin modifiers and remodellers: regulators of cellular differentiationGene regulatory networks governing lung specification.Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women.Chromatin sampling--an emerging perspective on targeting polycomb repressor proteinsA systems view of epigenetic networks regulating pancreas development and β-cell functionTEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.A stationary wavelet entropy-based clustering approach accurately predicts gene expressionEpigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.Chromatin states modify network motifs contributing to cell-specific functions.Tshz1 Regulates Pancreatic β-Cell Maturation.SETD7 Regulates the Differentiation of Human Embryonic Stem Cells.Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo.Minireview: Directed Differentiation and Encapsulation of Islet β-Cells-Recent Advances and Future Considerations.Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element.JMJD3 aids in reprogramming of bone marrow progenitor cells to hepatic phenotype through epigenetic activation of hepatic transcription factors.ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β CellsHow to make a functional β-cellBrief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cellsMatched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions.Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors.Stem Cells in the Treatment of Insulin-Dependent Diabetes Mellitus.
P2860
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P2860
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Dynamic chromatin remodeling m ...... of human embryonic stem cells.
@en
type
label
Dynamic chromatin remodeling m ...... of human embryonic stem cells.
@en
prefLabel
Dynamic chromatin remodeling m ...... of human embryonic stem cells.
@en
P2093
P2860
P1433
P1476
Dynamic chromatin remodeling m ...... of human embryonic stem cells.
@en
P2093
Allan J Robins
Allen Wang
Evert Kroon
Hee-Woong Lim
Jonathan Schug
Kevin A D'Amour
Klaus H Kaestner
Kyoung-Jae Won
Logan J Everett
Maike Sander
P2860
P304
P356
10.1016/J.STEM.2012.11.023
P407
P577
2013-01-11T00:00:00Z