Class 1A PI3K regulates vessel integrity during development and tumorigenesis. - Wikidata - awgldk - TriplyDB

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

http://www.wikidata.org/entity/Q36755338

about

Should individual PI3 kinase isoforms be targeted in cancer?PI3K/PTEN signaling in angiogenesis and tumorigenesis PI3K at the crossroads of tumor angiogenesis signaling pathways Temsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expression A computational tool for quantitative analysis of vascular networks Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy Targeting the phosphoinositide 3-kinase pathway in cancer Normalization of the vasculature for treatment of cancer and other diseases.Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.Plastic roles of pericytes in the blood-retinal barrier.The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways Blocking the mTOR pathway: a drug discovery perspective.Near-infrared fluorescence imaging for noninvasive trafficking of scaffold degradation.Clinical development of phosphatidylinositol-3 kinase pathway inhibitors PIK3CA(H1047R)- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling.Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression.TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5 Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors.Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy.Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.Novel inhibitors of the PI3K family.Inhibitors of phosphatidylinositol-3-kinase in cancer therapy ATP-competitive inhibitors of mTOR: new perspectives in the treatment of renal cell carcinoma.The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies.Therapeutic applications of PI3K inhibitors in cardiovascular diseases.PI3K in cancer-stroma interactions: bad in seed and ugly in soil.The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.Inhibiting the PI3K signaling pathway: buparlisib as a new targeted option in breast carcinoma.Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway.Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases.PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment.PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations.Role of a novel benzoxazine derivative in the chemosensitization of colon cancer.Myocardial fat overgrowth in Proteus syndrome

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P2860

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

http://www.wikidata.org/entity/Q36755338

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

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Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

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Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

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Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

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prefLabel

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

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Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

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PNAS.0804123105

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

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P2093

Aya Matsui

http://www.w3.org/2001/XMLSchema#string

Cyril Benes

http://www.w3.org/2001/XMLSchema#string

Eugene Lifshits

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Hak Soo Choi

http://www.w3.org/2001/XMLSchema#string

Ji Luo

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Tina L Yuan

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P2860

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

The phosphoinositide 3-kinase pathway

High frequency of mutations of the PIK3CA gene in human cancers

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

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105

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Lewis C. Cantley

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5230236

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