Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
about
Should individual PI3 kinase isoforms be targeted in cancer?PI3K/PTEN signaling in angiogenesis and tumorigenesisPI3K at the crossroads of tumor angiogenesis signaling pathwaysTemsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expressionA computational tool for quantitative analysis of vascular networksTargeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapyTargeting the phosphoinositide 3-kinase pathway in cancerNormalization of the vasculature for treatment of cancer and other diseases.Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.Plastic roles of pericytes in the blood-retinal barrier.The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathwaysBlocking the mTOR pathway: a drug discovery perspective.Near-infrared fluorescence imaging for noninvasive trafficking of scaffold degradation.Clinical development of phosphatidylinositol-3 kinase pathway inhibitorsPIK3CA(H1047R)- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling.Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancerOverexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression.TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors.Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy.Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.Novel inhibitors of the PI3K family.Inhibitors of phosphatidylinositol-3-kinase in cancer therapyATP-competitive inhibitors of mTOR: new perspectives in the treatment of renal cell carcinoma.The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies.Therapeutic applications of PI3K inhibitors in cardiovascular diseases.PI3K in cancer-stroma interactions: bad in seed and ugly in soil.The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.Inhibiting the PI3K signaling pathway: buparlisib as a new targeted option in breast carcinoma.Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway.Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases.PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment.PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations.Role of a novel benzoxazine derivative in the chemosensitization of colon cancer.Myocardial fat overgrowth in Proteus syndrome
P2860
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P2860
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
@ast
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
@en
type
label
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
@ast
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
@en
prefLabel
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
@ast
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
@en
P2093
P2860
P356
P1476
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
@en
P2093
Aya Matsui
Cyril Benes
Eugene Lifshits
Hak Soo Choi
Tina L Yuan
P2860
P304
P356
10.1073/PNAS.0804123105
P407
P577
2008-07-10T00:00:00Z