Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.
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Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase deltaEukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors.Definition of herpes simplex virus type 1 helper activities for adeno-associated virus early replication eventsInteractions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments.Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and managementAutographa californica multiple nucleopolyhedrovirus DNA polymerase C terminus is required for nuclear localization and viral DNA replicationAmino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agentsA point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.Mutation of the aspartic acid residues of the GDD sequence motif of poliovirus RNA-dependent RNA polymerase results in enzymes with altered metal ion requirements for activity.Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.Interaction of herpes simplex virus type 1 DNA polymerase and the UL42 accessory protein with a model primer templateHelicase-primase complex of herpes simplex virus type 1: a mutation in the UL52 subunit abolishes primase activity.Bacteriophage T4 DNA polymerase mutations that confer sensitivity to the PPi analog phosphonoacetic acid.Enzymatic activity of poliovirus RNA polymerases with mutations at the tyrosine residue of the conserved YGDD motif: isolation and characterization of polioviruses containing RNA polymerases with FGDD and MGDD sequencesIn vitro expression of the human cytomegalovirus DNA polymerase gene: effects of sequence alterations on enzyme activity.In vitro enzymatic activity of human immunodeficiency virus type 1 reverse transcriptase mutants in the highly conserved YMDD amino acid motif correlates with the infectious potential of the proviral genome.Use of suppressor analysis to identify DNA polymerase mutations in herpes simplex virus which affect deoxynucleoside triphosphate substrate specificity.Enzymatic activity of poliovirus RNA polymerase mutants with single amino acid changes in the conserved YGDD amino acid motif.A point mutation within conserved region VI of herpes simplex virus type 1 DNA polymerase confers altered drug sensitivity and enhances replication fidelity.Application of real-time PCR for determination of antiviral drug susceptibility of herpes simplex virus.Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids.An aspartic acid at amino acid 108 is required to rescue infectious virus after transfection of a poliovirus cDNA containing a CGDD but not SGDD amino acid motif in 3DpolMutations in two cysteine-histidine-rich clusters in adenovirus type 2 DNA polymerase affect DNA binding.Genetic identification and nucleotide sequence of the DNA polymerase gene of African swine fever virus.A DNA polymerase from the archaeon Sulfolobus solfataricus shows sequence similarity to family B DNA polymerases.Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site."The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.
P2860
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P2860
Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Engineered herpes simplex viru ...... lved in substrate recognition.
@en
type
label
Engineered herpes simplex viru ...... lved in substrate recognition.
@en
prefLabel
Engineered herpes simplex viru ...... lved in substrate recognition.
@en
P2093
P2860
P1433
P1476
Engineered herpes simplex viru ...... lved in substrate recognition.
@en
P2093
P2860
P304
P407
P577
1990-12-01T00:00:00Z