RNA toxicity in polyglutamine disorders: concepts, models, and progress of research
about
DNA triplet repeat expansion and mismatch repairCurrent understanding of the role of microRNAs in spinocerebellar ataxiasOligonucleotide-based strategies to combat polyglutamine diseases.Two enhancers control transcription of Drosophila muscleblind in the embryonic somatic musculature and in the central nervous system.Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington's Disease (HD) and Spinocerebellar Ataxias (SCAs)Huntingtin Exists as Multiple Splice Forms in Human Brain.Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA RepeatsRegulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs.RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases.A flexible polyglutamine hinge opens new doors for understanding huntingtin functionDrosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular DiseasesReduction of Huntington's Disease RNA Foci by CAG Repeat-Targeting Reagents.Allele-selective suppression of mutant genes in polyglutamine diseases.Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture.Modeling simple repeat expansion diseases with iPSC technology.Can Human Pluripotent Stem Cell-Derived Cardiomyocytes Advance Understanding of Muscular Dystrophies?Nanoparticulate strategies for the treatment of polyglutamine diseases by halting the protein aggregation process.RNA toxicity and foci formation in microsatellite expansion diseases.Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila.Self-duplexing CUG repeats selectively inhibit mutant huntingtin expressionA brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases.CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.Huntington Disease: Genetics, Prevention, and Therapy Approaches.A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases.Coiled-coil motifs enhance the toxicity of polyQ proteins (comment on DOI 10.1002/bies.201300001).Selection pressure on human STR loci and its relevance in repeat expansion disease.
P2860
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P2860
RNA toxicity in polyglutamine disorders: concepts, models, and progress of research
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
RNA toxicity in polyglutamine disorders: concepts, models, and progress of research
@en
type
label
RNA toxicity in polyglutamine disorders: concepts, models, and progress of research
@en
prefLabel
RNA toxicity in polyglutamine disorders: concepts, models, and progress of research
@en
P2860
P1476
RNA toxicity in polyglutamine disorders: concepts, models, and progress of research
@en
P2860
P2888
P304
P356
10.1007/S00109-013-1016-2
P577
2013-03-20T00:00:00Z
2013-06-01T00:00:00Z