Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters.
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Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylationThe SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions.N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-ablDown regulation by p60v-src of genes specifically expressed and developmentally regulated in postmitotic quail neuroretina cellsA conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell.Activation of YRP kinase by v-Src and protein kinase C-mediated signal transduction pathwaysSignal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.Structural differences between repressed and derepressed forms of p60c-srcBiological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts.Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein.Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutantsBiochemical properties of p60v-src mutants that induce different cell transformation parameters.Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants.Analysis of p60v-src mutants carrying lesions involved in temperature sensitivityThe membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.Rous sarcoma virus mutant dlPA105 induces different transformed phenotypes in quail embryonic fibroblasts and neuroretina cells.A single point mutation has pleiotropic effects on pp60v-src function.Transformation of chicken embryo fibroblast cells by avian retroviruses containing the human Fyn gene and its mutated genes.
P2860
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P2860
Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Genetic analysis of p60v-src d ...... ell transformation parameters.
@en
type
label
Genetic analysis of p60v-src d ...... ell transformation parameters.
@en
prefLabel
Genetic analysis of p60v-src d ...... ell transformation parameters.
@en
P2093
P2860
P1433
P1476
Genetic analysis of p60v-src d ...... ell transformation parameters.
@en
P2093
H Hanafusa
T Hanafusa
P2860
P304
P407
P577
1986-12-01T00:00:00Z