Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity.
about
Characterization of a novel member of the DOK family that binds and modulates Abl signalingA limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interactionMutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinaseIdentification of a unique Marek's disease virus gene which encodes a 38-kilodalton phosphoprotein and is expressed in both lytically infected cells and latently infected lymphoblastoid tumor cellsN-terminal mutations activate the leukemogenic potential of the myristoylated form of c-ablTransformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cellsAbelson murine leukemia virus variants with increased oncogenic potential.In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residuesIsolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogeneVariable expression of the translocated c-abl oncogene in Philadelphia-chromosome-positive B-lymphoid cell lines from chronic myelogenous leukemia patientsThe COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity.Insertional mutagenesis of the Abelson murine leukemia virus genome: identification of mutants with altered kinase activity and defective transformation ability.Oncogenic activation of c-ABL by mutation within its last exon.Expression of the Marek's disease virus homolog of herpes simplex virus glycoprotein B in Escherichia coli and its identification as B antigenThe BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells.A novel gene product associated with mu chains in immature B cells.Mutations in the signal sequence of prepro-alpha-factor inhibit both translocation into the endoplasmic reticulum and processing by signal peptidase in yeast cells.The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.Sequence-specific binding of DNA by the Moloney murine leukemia virus integrase protein.Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures.Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules.Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase propertiesExpression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related proteinThe minimum transforming region of v-abl is the segment encoding protein-tyrosine kinase.Generation of a recombinant Moloney murine leukemia virus carrying the v-src gene of avian sarcoma virus: transformation in vitro and pathogenesis in vivo.Use of site-specific antipeptide antibodies to perturb the serine kinase catalytic activity of p37mos.Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cellsA membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitroNormal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene productsCell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.Monoclonal antibodies to gp110 and gp41 of human immunodeficiency virus.Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation.A temperature-sensitive mutant of Abelson murine leukemia virus confers inducibility of IgM expression to transformed lymphoid cells.
P2860
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P2860
Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年論文
@yue
1984年論文
@zh-hant
1984年論文
@zh-hk
1984年論文
@zh-mo
1984年論文
@zh-tw
1984年论文
@wuu
1984年论文
@zh
1984年论文
@zh-cn
name
Only site-directed antibodies ...... in neutralize kinase activity.
@en
type
label
Only site-directed antibodies ...... in neutralize kinase activity.
@en
prefLabel
Only site-directed antibodies ...... in neutralize kinase activity.
@en
P2093
P2860
P1433
P1476
Only site-directed antibodies ...... ein neutralize kinase activity
@en
P2093
A S Ponticelli
J B Konopka
L Schiff-Maker
N Rosenberg
S M Watanabe
P2860
P304
P407
P577
1984-07-01T00:00:00Z