Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
about
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemiaA dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesisTherapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and LeukemiaInterconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemiaModeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.Notch target gene deregulation and maintenance of the leukemogenic phenotype do not require RBP-J kappa in Ikaros null mice.The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.Notch dimerization is required for leukemogenesis and T-cell development.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Cyclin C is a haploinsufficient tumour suppressor.Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemiaMutation of inhibitory helix-loop-helix protein Id3 causes γδ T-cell lymphoma in mice.The evolution of thymic lymphomas in p53 knockout miceGAS6 receptor status is associated with dormancy and bone metastatic tumor formationGrowth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.Notch Signaling in T-Cell Development and T-ALLCell of origin strongly influences genetic selection in a mouse model of T-ALLTrib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.The requirement for cyclin D function in tumor maintenance.Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cellsMicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid MalignanciesCharacterization of transgenic mice expressing cancer-associated variants of human NOTCH1Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia.Murine leukemia virus envelope gp70 is a shared biomarker for the high-sensitivity quantification of murine tumor burden.Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia.Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas.
P2860
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P2860
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
@en
type
label
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
@en
prefLabel
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
@en
P2093
P2860
P356
P1476
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
@en
P2093
Alexei Protopopov
Fotini Gounari
Harald von Boehmer
Khashayarsha Khazaie
P2860
P304
P356
10.1084/JEM.20081561
P407
P577
2008-11-03T00:00:00Z