The binding sites for benztropines and dopamine in the dopamine transporter overlap.
about
R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuseDesigning modulators of monoamine transporters using virtual screening techniquesNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesHow LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transportersNeurotransmitter and psychostimulant recognition by the dopamine transporter.Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulationsDe novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorderPIP2 regulates psychostimulant behaviors through its interaction with a membrane protein.Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling.Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporterEvolution of a Compact Photoprobe for the Dopamine Transporter Based on (±)-threo-Methylphenidate.Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analoguesInteraction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113.Monoamine transporter structure, function, dynamics, and drug discovery: a computational perspective.Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.The solute carrier 6 family of transportersSteric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporterRigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine.Chloride binding site of neurotransmitter sodium symporters.Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporterInteraction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling.Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters.Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter-In Silico and In Vitro Exploration of Dissociative Diarylethylamines.
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P2860
The binding sites for benztropines and dopamine in the dopamine transporter overlap.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The binding sites for benztropines and dopamine in the dopamine transporter overlap.
@en
type
label
The binding sites for benztropines and dopamine in the dopamine transporter overlap.
@en
prefLabel
The binding sites for benztropines and dopamine in the dopamine transporter overlap.
@en
P2093
P2860
P50
P1433
P1476
The binding sites for benztropines and dopamine in the dopamine transporter overlap
@en
P2093
Amy Hauck Newman
Heidi Bisgaard
M Andreas B Larsen
Sonia Mazier
Thijs Beuming
P2860
P304
P356
10.1016/J.NEUROPHARM.2010.08.021
P577
2010-09-06T00:00:00Z