Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization
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Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ CyclingPronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbitsStructural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T).Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-specific differences in ventricular refractoriness and His conduction.Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo.Resolving the M-cell debate: why and how.Proteomic analyses of transgenic LQT1 and LQT2 rabbit hearts elucidate an increase in expression and activity of energy producing enzymes.How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity.Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protectiveCase scenario: anesthesia-related cardiac arrest in a child with Timothy syndrome.Transgenic rabbit models for studying human cardiovascular diseases.A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene.Propofol-associated QTc prolongationOn the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools.Interaction between the cardiac rapidly (IKr) and slowly (IKs) activating delayed rectifier potassium channels revealed by low K+-induced hERG endocytic degradation.AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model.Blockade of the human ether-a-go-go-related gene potassium channel by ketamine.Effects of deep sedation on cardiac electrophysiology in patients undergoing radiofrequency ablation of supraventricular tachycardia: impact of propofol and ketamine.Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome.
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P2860
Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Pharmacogenomics of anesthetic ...... ects on cardiac repolarization
@en
Pharmacogenomics of anesthetic ...... cts on cardiac repolarization.
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type
label
Pharmacogenomics of anesthetic ...... ects on cardiac repolarization
@en
Pharmacogenomics of anesthetic ...... cts on cardiac repolarization.
@nl
prefLabel
Pharmacogenomics of anesthetic ...... ects on cardiac repolarization
@en
Pharmacogenomics of anesthetic ...... cts on cardiac repolarization.
@nl
P2093
P2860
P1476
Pharmacogenomics of anesthetic ...... ects on cardiac repolarization
@en
P2093
Gideon Koren
Katja E Odening
Leonard Chaves
Lorraine Schofield
Malcolm Kirk
Manfred Zehender
Michael Brunner
Omar Hyder
Xuwen Peng
P2860
P304
P356
10.1152/AJPHEART.00680.2008
P577
2008-10-03T00:00:00Z