Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta
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Preclinical efficacy of cystatin C to target the oncogenic activity of transforming growth factor Beta in breast cancerNon-Smad pathways in TGF-beta signalingTGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages.Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition.p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors.TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism.PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis.Mechanisms of the epithelial-mesenchymal transition by TGF-betaSrc kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB.Crosstalk between the p38 and TGF-β signaling pathways through TβRI, TβRII and Smad3 expression in plancental choriocarcinoma JEG-3 cells.TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-β signaling pathwayThe molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts.Genomic profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization.Role of Sema4C in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells.Transforming growth factor-β and the hallmarks of cancer.Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-β signaling in breast cancer cells.KEGGgraph: a graph approach to KEGG PATHWAY in R and bioconductor.Mechanisms of TGF-β-induced differentiation in human vascular smooth muscle cellsSignaling mechanisms of the epithelial-mesenchymal transition.The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cellsSilencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple-Negative Breast Cancer.PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer.TGF-β upregulates miR-181a expression to promote breast cancer metastasis.Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells.TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer.Noncanonical TGF-β signaling during mammary tumorigenesis.Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression.Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism.The relevance of the TGF-β Paradox to EMT-MET programsThe TGF-beta paradox in human cancer: an update.Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-βPhospho-control of TGF-beta superfamily signaling.Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation.Breast cancer-derived factors stimulate osteoclastogenesis through the Ca2+/protein kinase C and transforming growth factor-beta/MAPK signaling pathways.Upregulated WAVE3 expression is essential for TGF-β-mediated EMT and metastasis of triple-negative breast cancer cells.Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasisProtein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.
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Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Grb2 binding to Tyr284 in Tbet ...... astasis stimulated by TGF-beta
@en
Grb2 binding to Tyr284 in Tbet ...... stasis stimulated by TGF-beta.
@nl
type
label
Grb2 binding to Tyr284 in Tbet ...... astasis stimulated by TGF-beta
@en
Grb2 binding to Tyr284 in Tbet ...... stasis stimulated by TGF-beta.
@nl
prefLabel
Grb2 binding to Tyr284 in Tbet ...... astasis stimulated by TGF-beta
@en
Grb2 binding to Tyr284 in Tbet ...... stasis stimulated by TGF-beta.
@nl
P2860
P356
P1433
P1476
Grb2 binding to Tyr284 in Tbet ...... astasis stimulated by TGF-beta
@en
P2093
Amy J Galliher-Beckley
William P Schiemann
P2860
P304
P356
10.1093/CARCIN/BGM245
P407
P577
2008-01-03T00:00:00Z