Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response.
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Targeting molecular addictions in cancerWZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site.O-GlcNAcylation: The Sweet Side of the Cancer.PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.System-wide characterization of bZIP transcription factor proteins involved in infection-related morphogenesis of Magnaporthe oryzae.Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and AnoikisPPAR-delta promotes survival of breast cancer cells in harsh metabolic conditionsIntegrated omics-analysis reveals Wnt-mediated NAD+ metabolic reprogramming in cancer stem-like cells.Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.AMP-activated protein kinase α2 protects against liver injury from metastasized tumors via reduced glucose deprivation-induced oxidative stressCellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update.Role of O-GlcNAcylation in nutritional sensing, insulin resistance and in mediating the benefits of exercise.Targeting cancer cell metabolism in pancreatic adenocarcinoma.The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors.Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.The unfolded protein response in glioblastomas: targetable or trouble?Drosophila melanogaster activating transcription factor 4 regulates glycolysis during endoplasmic reticulum stress.A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect.Can UPR integrate fasting and stem cell regeneration?Bottom-up proteomics analysis of the secretome of murine islets of Langerhans in elevated glucose levels.SG2NA is a regulator of endoplasmic reticulum (ER) homeostasis as its depletion leads to ER stress.Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis.How does oncogene transformation render tumor cells hypersensitive to nutrient deprivation?Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells.O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance.Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring.
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Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Glucose starvation induces cel ...... the unfolded protein response.
@en
Glucose starvation induces cel ...... the unfolded protein response.
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type
label
Glucose starvation induces cel ...... the unfolded protein response.
@en
Glucose starvation induces cel ...... the unfolded protein response.
@nl
prefLabel
Glucose starvation induces cel ...... the unfolded protein response.
@en
Glucose starvation induces cel ...... the unfolded protein response.
@nl
P2093
P2860
P50
P356
P1476
Glucose starvation induces cel ...... the unfolded protein response.
@en
P2093
A Monestiroli
F P Cammarata
R Palorini
P2860
P356
10.1038/CDDIS.2013.257
P577
2013-07-18T00:00:00Z